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DIT > exotoxins > Flashcards

exotoxins Flashcards

1
Q

G+ or G- produce exotoxins

A

Gram positives

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2
Q

inhibits ACh release, flaccid paralysis

A

botulinum

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3
Q

phospholipase that causes gas gangrene

A

clostridium alpha toxin

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4
Q

inhibits the inhibitor of adenylate cyclase -> whooping cough

A

pertussis toxin

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5
Q

stimulates adenylate cyclase -> chloride and water into gut, diarrhea

A

cholera and heat-labile ETEC

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6
Q

destroys leukocytes

A

s. aurues

hemolysis and panton-valentine leukoceidin

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7
Q

composed of edema factor, lethal factor, and protective antigen

A

anthracis

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8
Q

enterotoxin causing rice-water diarrhea

A

vibrio cholera, heat labile ETEC

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9
Q

causes scarlet fever

A

strep pyogenes

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10
Q

causes toxic shock syndrome

A

TSST-1 (s aureus)

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11
Q

inactivates EF-2 -> pseudomembranous pharyngitis

A

diptheria

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12
Q

inactivates EF-2 -> host cell death

A

exotoxin A from Pseudomonas

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13
Q

blocks the release of the inhibitory neurotransmitter glycine

A

tetanospasmin

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14
Q

corynebacterium diptheriae

A

diphtheria toxin (inactivates EF-2)

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15
Q

Pseudomonas

A

exotoxin A (inactivates EF-2 and causes cell death)

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16
Q

Shigella

A 
shiga toxin (inactivates 60S ribosomes)
GI mucosal damage -> dysentery, HUS
17
Q

Enterohemorrhagic E. coli (o157:H7)

A

shiga-like toxin (inactivates 60S ribosome)

HUS and bloody diarrhea

18
Q

ETEC

A

Heat-labile (overactivates adenylate cyclase -> increases Cl secretion)
heat-stable (overactivates guanylate cyclase -> decrease NaCL resorption)
both cause watery diarrhea

19
Q

bacillus anthracis

A 
edema factor (mimics adenylate cyclase)
black eschar
20
Q

vibrio cholerae

A

cholera toxin (overactivates adenylate cyclase by permanently activating Gs)

21
Q

Bordatella pertussis

A

overactivates adenylate cyclase by disabling Gi

whooping cough

22
Q

Clostridium tetani

A

tetanospasmin cleaves SNARE

prevents release of GABA and glycine

23
Q

clostridium botulinum

A

botulinum toxins A-G cleave SNARE

flaccid paralysis prevents stimulatory ACh signals

24
Q

clostridium perfringens

A

alpha toxin degrades tissue and cell membranes (phospholipase)
myenecrosis and hemolysis because of degradation of phospholipase C

25
Q

streptococcus pyogenes

A

streptolysin O degrades cell membranes and lyses RBC

antibodies used to diagnose rheumatic fever

26
Q

staphylococcus aureus

A

toxic shock syndrome toxin (TSST-1) acts as superantigen

27
Q

streptococcus pyogenes

A

Exotoxin A acts as superantigen

DIT (28 decks)

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