Autoantibodies

Question 1

anti-IgG

Answer 1

Rheumatoid arthritis

Question 2

anti-citrullinated protein antibodies (ACPA)

Answer 2

Rheumatoid arthritis

Question 3

anti-centromere

Answer 3

CREST scleroderma

Question 4

anti-Scl-70 (antitopoisomerase)

Answer 4

diffuse scleroderma

Question 5

anti-histone

Answer 5

drug-induced lupus

SHIPP: Sulfonamides, Hydralazine, Isoniazid, Phenytoin, Procainamide

Question 6

antinuclear antibodies (ANA)

Answer 6

SLE

Question 7

anti-Smith

Answer 7

SLE (specific)

Question 8

anti-dsDNA

Answer 8

lupus nephritis (SLE)

Question 9

anti-Jo-1

Answer 9

polymyositis/dermatomyositis

Question 10

anti-SSA (Ro)

Answer 10

Sjogren

Question 11

anti-SSB (La)

Answer 11

Sjogren

Question 12

anti-U1-RNP

Answer 12

mixed connective tissue disease

Question 13

anti-desmoglein

Answer 13

pemphigus vulgaris

Question 14

anti-ACh receptor

Answer 14

myasthenia gravis

Question 15

anti-endomysial (transglutaminase)

Answer 15

Celiac

Question 16

anti-gliadin

Answer 16

Celiac

Question 17

anti-mitochondrial

Answer 17

primary biliary cirrhosis

Question 18

anti-smooth muscle

Answer 18

autoimmune hepatitis

Question 19

anti-glutamate decarboxylase

Answer 19

type I Db

Question 20

anti-thyrotropin receptor

Answer 20

Graves disease

Question 21

anti-thyroid peroxidase (anti-TPO)

Answer 21

Hashimoto thyroiditis

Question 22

anti-thyroglobulin

Answer 22

Hashimoto or Graves

Question 23

anti-basement membrane

Answer 23

Goodpasture’s

Question 24

c-ANCA

Answer 24

Granulomatosis w/ polyangitis (Wegener’s)

Question 25

p-ANCA

Answer 25

pauci-immune crescentic glomerulonephritis Churg-Strauss Microscopic polyangitis

Question 26

anti-hemidesmosomes

Answer 26

Bullous Pemphigoid