Autoantibodies Flashcards

1
Q

anti-IgG

A

Rheumatoid arthritis

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2
Q

anti-citrullinated protein antibodies (ACPA)

A

Rheumatoid arthritis

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3
Q

anti-centromere

A

CREST scleroderma

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4
Q

anti-Scl-70 (antitopoisomerase)

A

diffuse scleroderma

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5
Q

anti-histone

A

drug-induced lupus

SHIPP: Sulfonamides, Hydralazine, Isoniazid, Phenytoin, Procainamide

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6
Q

antinuclear antibodies (ANA)

A

SLE

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7
Q

anti-Smith

A

SLE (specific)

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8
Q

anti-dsDNA

A

lupus nephritis (SLE)

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9
Q

anti-Jo-1

A

polymyositis/dermatomyositis

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10
Q

anti-SSA (Ro)

A

Sjogren

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11
Q

anti-SSB (La)

A

Sjogren

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12
Q

anti-U1-RNP

A

mixed connective tissue disease

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13
Q

anti-desmoglein

A

pemphigus vulgaris

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14
Q

anti-ACh receptor

A

myasthenia gravis

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15
Q

anti-endomysial (transglutaminase)

A

Celiac

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16
Q

anti-gliadin

A

Celiac

17
Q

anti-mitochondrial

A

primary biliary cirrhosis

18
Q

anti-smooth muscle

A

autoimmune hepatitis

19
Q

anti-glutamate decarboxylase

A

type I Db

20
Q

anti-thyrotropin receptor

A

Graves disease

21
Q

anti-thyroid peroxidase (anti-TPO)

A

Hashimoto thyroiditis

22
Q

anti-thyroglobulin

A

Hashimoto or Graves

23
Q

anti-basement membrane

A

Goodpasture’s

24
Q

c-ANCA

A

Granulomatosis w/ polyangitis (Wegener’s)

25
Q

p-ANCA

A

pauci-immune crescentic glomerulonephritis
Churg-Strauss
Microscopic polyangitis

26
Q

anti-hemidesmosomes

A

Bullous Pemphigoid