Cytokines and Interferons Flashcards
IL-1
acute phase (pyrogenic) macrophage activates endothelium to express adhesion molecules
IL-6
acute phase (pyrogenic) macrophages and Th2
IL-8
chemotactic factor for neutrophils
macrophage
IL-12
induce T cell differentiation to Th1
activates NK cells
macrophages and B cells
TNF-alpha
mediates septic shock
leukocyte recruitment, vascular leak
macrophages
IL-2
stimulates T cell growth
all t cells
IL-3
growth and differentiation of bone marrow stem cells. Like GM-CSF
all t cells
IFN-gamma
activates macrophages and Th1 cells suppress Th2 cells activates NK cells increases MHC I and II expression Th1
IL-4
differentiation to Th2
class switching to IgE and IgG
Th2
IL-5
class switching to IgA
growth of eosinophils
Th2
IL-10
modulates inflammatory response
inhibits Th1 and macrophages
similar to TGF-B
Th2
Neutrophil chemotactic factors
IL-8, C5a, LKTB4
IFN-a and B
inhibit viral protein synthesis
Interferon mechanism
induce production of ribonuclease that inhibits viral protein synthesis
Aldesleukin
IL-2
renal cell carcinoma, metastatic melanoma
Epoetin alfa
erythropoietin
anemias (especially in renal failure)
Filgrastim
G-CSF
recovery of bone marrow
Sargramostim
GM-CSF
recovery of bone marrow
a-interferon
hepatitis B and C, Kaposi’s sarcoma, leukemias, malignant melanoma
B-interferon
multiple sclerosis
G-interferon
chronic granulomatis disease
Oprelvekin
(IL-11)
Thrombocytopenia
Thrombopoietin
thrombocytopenia
mediate inflammation
IL-1, 6 TNF-a
