Micro Flashcards
ampicillin/amoxicillin coverage
G(+) and HELPSS Haemophilus E. coli Listeria Proteus Salmonella Shigella
organisms not covered by cephalosporins
LAME Listeria atypicals (chlamydia, mycoplasma) MRSA Enterococci
first gen cephalosporins
cefazolin, cephalexin
PEcK and G(+)
Proteus, E. coli, Klebsiella
second gen cephalosporins
cefoxitin, cefaclor, cefuroxime HENS PEcK Haemophilus Enterobacter Neisseria (not gonorrhea) Serratia Proteus, E. coli, Klebsiella
third gen cephalosporins
ceftriaxone (excreted in bile), cefotazime, ceftazidime
G(-) bad guys
meningitis and gonorrhea
ceftazidime for pseudomonas
fourth gen cephalosporins
cefepime
good pseudomonas and broad G(+)
toxicity of cephalosporins
increased nephrotoxicity with aminoglycosides
disulfiram like reaction
given prior to surgery to prevent s. aureus infections
cefazolin (1st gen)
side effects of vancomycin
red man syndrome (mast cell degranulation)
NOT: nephrotoxicity, ototoxicity, thrombophlebitis
resistance to vancomycin
change of D-ala-D-ala to D-ala-D-lac
protein synthesis inhibitors
Buy AT 30, CELL at 50
30s: aminoglycosides, tetracyclines
50s: chloramphenicol, clindamycin, erythromycin (macrolides), linezolid
use for tetracyclines
VACUUM THe BedRoom vibrio cholera acne chlamydia ureaplasma urealyticum mycoplasma pneumoniae tularemia H. pylori Borrelia burgdorferi Rickettsia
photosensitivity
SAT:
sulfonamides, amiodarone, tetracyclines
what to avoid with tetracyclines
milk, antacids, iron because they inhibit the absorption of tetracyclines
given for bowel surgery
neomycin
toxicity of aminoglycosides
nephrotoxicity, ototoxicity, teratogenic
clinical uses for macrolides
PUS
Pneumonia: mycoplasma, chlamydia, legionella
URI: strep pneumoniae, strep pyogenes
STD: chlamydia, gonorrhea
resistance to macrolides
mehtylation of 23S RNA subunit of 50S
clinical use for chloramphenicol and toxicity
use: meningitis (H. flu, N men, strep pneum)
tox: gray baby syndrome, aplastic anemia
clinical use of clindamycin and toxicity
use: MRSA abscess
tox: C. difficile
streptogramins
quinupristin and dalfopristin
bind 23s subunit of 50s
use: MRSA, VRE, staph and strep skin infections
SE: hepatotoxicity, pseudomembranous colitis, inhibits cP450 system
what causes:
gray baby
gray man
red man
baby: chloramphenicol
man: amiodarone
red man: vancomycin
prophylaxis for meningococcal infection
coprofloxacin
rifampin for children
prophylaxis for gonorrhea
ceftriaxone
prophylaxis for syphilis
benzathine penicillin G
prophylaxis for history of recurrent UTI
TMP-SMX, nitrofurantoin, amoxicillin
prophylaxis for pneumocystic jiroveci
TMP-SMX if CD4<200, dapsone if sulfa allergic
prophylaxis for endocarditis (surgery or dental procedure)
penicillins, aminopenicillins, cephalexin
prophylaxis for pregnant women with Group B strep
ampicillin during pregnancy
prophylaxis for strep pharyngitis in child with prior rheumatic fever
oral penicillin
prophylaxis for postsurgical infection of s. aureus
cefazolin
prophylaxis for gonococal or chlamydial conjunctivitis in newborn
erythromycin ointment
antibiotics to avoid in pregnancy
SAFe Children Take Really Good Care Sulfonamides (kernicterus) Aminoglycosides (ototoxicity) Fluoroquinolones (cartilage damage) Clarithromycin (embryotoxic) Tetracylines (discolored teeth) Ribavirn (teratogenic) Griseofulvin (teratogenic) Chlorammphenicol (Gray baby) also metronidazole (mutagenesis 1st trimester)
antiplatelet antibodies
ITP: immunothrombocytopenia
newborn with chronic diarrhea, failure to thrice, and chronic Candida
SCID
child with eczema, coarse facial features, and cold abscesses
heyperimmunogloculinemia E syndrome (Job syndrome)
child with partial albinism, peripheral neuropathy, and recurrent infections
Chediak-Higashi
oropharynx colonized by
viridans streptococci
dental plaque
strep mutans
colon
Bacteroides fragilis>E. coli
vagina
lactobacillus; E. coli and group B strep sometimes
common cause of pneumonia in neonates
Group B strep
E. coli
Tx: ampicillin and gentamicin
common cause of pneumonia in children
RSV Mycoplasma Chlamydia S pneumoniae Tx: azithromycin or ceftriaxone
common cause of pneumonia in adults (<40)
Mycoplasma
C. pneumoniae
S. pneumoniae
Tx: azithromycin and ceftriaxone
common cause of pneumonia in adults (40-65)
S. pneumoniae
H influenzae
Tx: clarithromycin
common cause of pneumonia in elderly
S. pneumoniae influenza virus anaerobes H. influenzae Tx: cephapime or carbapenam
common cause of pneumonia in IV drug users
S. pneumoniae, Klebsiella, Staphylococcus
common cause of pneumonia cystic fibrosis
Pseudomonas, S. aureus, S pneumoniae
atypical pneumonia
Mycoplasma, Legionella, Chlamydia
postviral pneumonia
Staphylococcus, H flu, S pneumoniae
common cause of meningitis 0-6 months
Group B strep, E. coli, Listeria
common cause of meningitis <6
Strep pneumoniae, N. meningitidis, H flu, enterovirus (coxsackie A)
common cause of meningitis 6-60
S pneumoniae, n. meningitids, enterovirus, HSV
common cause of meningitis over 60
S. pneumoniae, G- rods, Listeria
common cause of meningitis in HIV
cryptococcus
osteomyelitis
S. aureus sexually active: N. gonorrhea Db and IV drugs: Pseudomonas, serratia Sickle cell: salmonella prosthetic replacement: S. aureus, S epidermidis vertebral disease: TB cat/dog bite: Pasteurella multocida
CSF findings in meningitis
bacterial: increased pressure, PMN, protein and decreased glucose
fungal: increased pressure, lymphocytes, protein and decreased glucose
viral: normal or increased pressure, increased lymphocytes and protein, normal glucose
most common etiology of bacterial meningitis
Group B strep
most common etiology of bacterial meningitis in kids
strep pneumoniae
n. meningitidis
most common bacterial meningitis in adults
S. pneumoniae
osteomyelitis in IV drug user
S. aureus or Pseudomonas
osteomyelitis in sickle cell
Salmonella
pt presents with vertigo, tinnitus, and hearing loss
Meneiere’s disease
TORCHeS infections
Toxoplasma gondii Other: parvovirus B19, meningitis Rubella CMV Herpes 2/HIV Syphilis
STD with clue cells
bacterial vaginosis
painless genital ulcer
syphilis
flagellated cells
trichomonas
strawberry cervix
trichomonas
most common reportable STD
Chlamydia
non-painful, indurated, ulcerated genital lesion
primary syphilis
painful, indurated, ulcerated genital lesion, with exudate
chancroid
stippled vaginal epithelial cells on a wet prep of vaginal discharge
bacterial vaginosis (clue cells)
common treatment for syphilis
penicillin G
common treatment for Trichomonas
metronidazole
common treatment for Chlamydia
doxycycline or azithromycin
common treatment for gonorrhea
ceftriaxone
toxoplasma gondii triad
chorioretinitis
hydrocephalus
intracranial calcifications
rubella triad
PDA
cataracts
deafness
CMV
hearing loss, seizures, blueberry muffin rash
vaginal discharge
young girl (puberty): physiological
cottage cheese: candidiasis
very itchy: trichomonas
fishy smell, clue cells: bacterial vaginosis
newborn nursery
CMV, RSV
urinary cath
E. coli, pseudomonas
respirator
Pseudomonas
renal dialysis
HBV
IV nutrition (hyperalimentation)
candida albicans
water aerosols
legionella
antibiotics safe during pregnancy
penicillins and aminopenicillins piperacillin cephalosporins macrolides metronidazole (after 1st trimester) nitrofurantoin
RUQ pain and symptoms of PID
Fitz-Hugh-Curtis syndrome
follows PID episode and is sudden onset RUQ pain and may show violin string adhesions on laparoscopy
do not take Gram stain
Treponema Rickettsia Mycobacteria (high lipid content) Mycoplasma (no cell wall) Legionella pneuomophila Chlamydia
Giemsa stain
Chlamydia, Borrelia, Rickettsiae, Trypanosomes, Pasmodium
PAS (peiodic acid-Schiff) stain
stains glycogen, mucopolysaccharides
Whipple’s disease (Tropheryma whipplei)
Ziehl-Neelsen (carbol fuchsin)
acid fact organisms
Nocardia and Mycobacterium
India ink stain
Cryptococcus neoformans
Silver stain
fungi, legionella, H. pylori
encapsulated bacteria
Strep pneumoniae Haemophilus influenzae N. meningitidis E. coli Pseudomonas Klebsiella Salmonella typhi
organism in balanitis
candida albicans
balanitis is inflammation of glans penis
obligate aerobes
Nocardia, Pseudomonas, Mycobacterium tuberculosis, Bacillus
obligate anaerobes
Clostridium, Bacteroides, Actinomyces
lack superoxide dismutase
endotoxin
ENDOTOXIN edema nitric oxide DIC/death outer membrane TNF-a O-antigen eXtremely heat stable IL-1 Neutrophil chemotaxis
transformation
take up naked DNA
conjugation
plasmid passing
transposition
transfer genes from plasmid to chromosome and vice versa
transduction
packaging of DNA in phages
what 7 bacteria secrete enterotoxins (exotoxins in GI system)
vibrio cholera, E. coloi, s. aureus, shigella, yersinia, c. difficile, clostridium perfringens
skin pathogen that infects indwelling foreign devices
s. epidermidis
organisms most likely in subacute endocarditis
viridans strep, enterococci, s. bovis, coagulase neg. staph and HACEK
Haemophilus, actinobacillus, cardiobacterium, eikenella, kingella