Norepinephrine G4 Flashcards
Norepinephrine Class
• Sympathomimetic
Norepinephrine MOA
• Alpha-adrenergic response
o Vasoconstriction
• Beta1-adrenergic responses
o Increases the heart rate
o Increases myocardial contractility
Norepinephrine Indication
• Severe hypotension refractory to IV boluses caused by
o Cariogenic shock
o Septic shock
o Neurogenic shock
Norepinephrine Adult dose
• Infusion:
0.1 to 2.0 mcg/kg/minute, titrated to effect
Norepinephrine Contraindications
• Hypotension caused by hypovolemia
Norepinephrine Adverse effects
• Extravasation of the IV/IO may cause tissue necrosis
• Tachycardia
• Increased myocardial oxygen demand
• Hypertension
• Dysrhythmias
Norepinephrine Pediatric dose
• Infusion:
0.05 to 0.1 mcg/kg/minute, titrated to effect