Amiodarone G3 Flashcards

1
Q

Amiodarone Class

A
  • Antiarrhythmic agent (Class III)
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2
Q

Amiodarone MOA

A
  • Potassium channel blocker slows ventricular automaticity.
  • Sodium channel blocker slows membrane depolarization & impulse conduction.
  • Calcium channel blocker & β-blocker: negative chronotropic activity in nodal tissue; rate reduction
  • Prolongs action potential and delays repolarization.
  • Decreases AV (atrioventricular) node conduction and SA (sinoatrial) node function
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3
Q

Amiodarone Indications

A
  • VF/PVT after CPR, defibrillation, and epinephrine
  • Stable, regular, narrow-complex tachycardia refractory to vagal maneuvers and adenosine
  • Control of ventricular rate in: AF with RVR without preexcitation; stable wide-complex tachycardia; stable monomorphic VT; polymorphic VT with a normal QT interval
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4
Q

Amiodarone Adult dose

A
  • VF/PVT:
    • 300 mg IV/IO push over a minute, may repeat one time in 3 – 5 min. with 150mg IV/IO slow push (if needed)
  • Wide-complex tachycardia, A-fib or flutter or SVT refractory to vagal maneuvers and adenosine:
    • 150mg in 100 mL NS IV/IO over 10min., may repeat in 10 min. (if needed)
  • Infusion (if needed for reperfusion arrhythmias) after ROSC:
    • 1 – 5 mg/min. IV/IO infusion (300mg in 100mL of NS = 3 mg/mL) over 24 hrs., (max dose 2.2 G/24 hrs.)
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5
Q

Amiodarone Contraindications

A
  • Known hypersensitivity to amiodarone or iodine
  • Cardiogenic shock
  • Second or third-degree AV blocks, sick-sinus syndrome, or other SA diseases without a functioning pacemaker
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6
Q

Amiodarone Adverse reactions

A
  • CV: hypotension, heart failure, prolonged QT interval, bradycardia, AV block, worsening of dysrhythmias
  • GI: nausea & vomiting
  • Other: dizziness, IV site irritation, Steven’s-Johnson Syndrome
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7
Q

Amiodarone Pediatric dose

A
  • V-fib/PVT:
    • 5mg/kg IV/IO push every 3-5 min, may repeat 3 times to max 15 mg/kg over 24 hrs. (max single dose of 300mg)
  • Poor perfusing ventricular or atrial rhythms with a pulse:
    • 5mg/kg IV/IO over 20-60 minutes, may repeat 3 times to 15 mg/kg over 24 hrs. (max single dose of 300mg)
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