Lorazepam G7

Question 1

Lorazepam Class

Answer 1

• Benzodiazepine
• Anticonvulsant
• Sedative
• Hypnotic

Question 2

Lorazepam MOA

Answer 2

• Produces sedation by acting on the limbic system, the thalamus, and cortex
• Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
• Raises the seizure threshold
• Produces tranquilizing (antianxiety) effect on the central nervous system

Question 3

Lorazepam Indications

Answer 3

• Seizure activity
• Status epilepticus
• Procedural sedation for intubation and cardioversion
• Chemical restraint for agitated (excited) delirium
• Severe anxiety

Question 4

Lorazepam Adult dose

Answer 4

• Seizure IV/IO/IM: 2.0 to 5.0 mg (IV over 2 min)
• Procedural sedation IV/IO: 2.0 mg over 2 min
• Procedural sedation IM: 4.0 mg
• Maximum dosage: 10 mg

Question 5

Lorazepam Contraindications

Answer 5

• Known hypersensitivity to the drug

Question 6

Lorazepam Adverse effects

Answer 6

• Sedation
• Transient amnesia
• Respiratory depression
• Respiratory arrest
• Bradycardia
• Hypotension

Question 7

Lorazepam Pediatric dose

Answer 7

• Seizure IV/IO/IM: 0.05 to 0.1 mg/kg over 2 min
• Maximum dosage 4.0 mg