Diazepam G8

Question 1

Diazepam Class

Answer 1

• Benzodiazepine
• Anticonvulsant
• Sedative
• Hypnotic

Question 2

Diazepam MOA

Answer 2

• Produces sedation by acting on the limbic system, the thalamus, and hypothalamus
• Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
• Raises the seizure threshold
• Produces tranquilizing (antianxiety) effect on the central nervous system

Question 3

Diazepam Indications

Answer 3

• Seizure activity
• Status epilepticus
• Procedural sedation for rapid sequence intubation and cardioversion
• Chemical restraint for agitated (excited) delirium
• Delirium tremens
• Severe anxiety

Question 4

Diazepam Adult dose

Answer 4

• 2.0 mg increments over 2 minutes

Question 5

Diazepam Contraindications

Answer 5

• Known hypersensitivity to the drug
• Head injury

Question 6

Diazepam Adverse effects

Answer 6

• Sedation
• Transient amnesia
• Respiratory depression
• Bradycardia
• Hypotension

Question 7

Diazepam Pediatric dose

Answer 7

• IV/IO: 0.2 to 0.3 mg/kg
• IM: 0.1 to 2.0 mg/kg
• Rectal: 0.2 to 0.5 mg/kg