Magnesium Sulfate G8

Question 1

Magnesium Sulfate Class

Answer 1

• Electrolyte
• Anti-inflammatory
• Tocolytic (labor suppressant)

Question 2

Magnesium Sulfate MOA

Answer 2

• Decreases ventricular irritability
• Decreases release of acetylcholine that inhibits muscular excitability
• Causes uterine relaxation
• Relaxes bronchial smooth muscle resulting in bronchodilation
• Raises the seizure threshold in eclampsia and preeclampsia

Question 3

Magnesium Sulfate Indications

Answer 3

• Seizures caused by toxicity of pregnancy (toxemia)
• Pregnancy induced hypertension (pre-eclampsia and eclampsia)
• Pre-term labor
• Torsades de Pointes (polymorphic ventricular tachycardia)
• Ventricular fibrillation and pulseless ventricular tachycardia refractory to
amiodarone or lidocaine
• Reactive airway conditions including bronchoconstriction and bronchospasm

Question 4

Magnesium Sulfate Adult dose

Answer 4

• Torsades de pointes infusion: 1.0 to 2.0 Gm in 50 to 100 mL over 5 minutes
• May repeat the dosage 1.0 to 2.0 Gm over 1 hour

• Pre-term labor/pre-eclampsia/eclampsia infusion: 3.0 to 6.0 Gm in 100 mL over 10 to 20 minutes may repeat the initial dosage

• Maintenance infusion: 1.0 to 4.0 Gm/hour

• Reactive airway conditions: 2.0 Gm in 50 mL over 5 to 10 minutes

• Cardiac arrest IV/IO: 1.0 to 2.0 Gm over 1 to 2 minutes

Question 5

Magnesium Sulfate Contraindications

Answer 5

• Hemodynamically significant heart block

Question 6

Magnesium Sulfate Adverse effects

Answer 6

• Central nervous system depression
• Drowsiness
• Hypotension
• Respiratory depression
• Dysrhythmias

Question 7

Magnesium Sulfate Pediatric dose

Answer 7

• Reactive airway conditions infusion:
25 to 50 mg/kg 10% solution infused over 15 to 30 minutes
• Maximum dosage 2.0 Gm