Midazolam G10

Question 1

Midazolam Class

Answer 1

• Benzodiazepine
• Anticonvulsant
• Sedative
• Hypnotic

Question 2

Midazolam MOA

Answer 2

• Produces sedation by acting on the limbic system, the thalamus, and hypothalamus
• Binds to gamma-amino butyric acid (GABA) benzodiazepine receptors in the brain
• Raises the seizure threshold
• Produces tranquilizing (antianxiety) effect on the central nervous system

Question 3

Midazolam Indications

Answer 3

• Seizure activity
• Status epilepticus
• Procedural sedation for intubation and cardioversion
• Chemical restraint for agitated (excited) delirium

Question 4

Midazolam Adult dose

Answer 4

• Seizure IV/IO: 0.1 mg/kg max dosage: 4.0 mg
• Seizure IM: 0.2 mg/kg max dosage: 10 mg
• Procedural sedation IV/IO: 0.5 to 2.5 mg max dosage: 0.1 mg/kg
• Chemical restraint IV/IO: 0.05 to 0.1 mg/kg
• Chemical restraint IM: 0.1 to 0.15 mg/kg

Question 5

Midazolam Contraindications

Answer 5

• Known hypersensitivity to the drug

Question 6

Midazolam Adverse effects

Answer 6

• Sedation
• Transient amnesia
• Respiratory depression
• Respiratory arrest
• Bradycardia

Question 7

Midazolam Pediatric dose

Answer 7

• Seizure IV/IO: 0.05 to 0.1 mg/kg
• Seizure IM: 0.2 mg/kg max dosage 10 mg
• Procedural sedation IV/IO: 0.05 to 0.5 mg/kg max dosage 0.1 mg/kg