neurons Flashcards

1
Q

what are neurons?

A
  • nerve cells
  • in nervous system
  • specialised for communication
  • connect with each other and with other excitable cells
  • many different types
  • structure is related to function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the parts of a neuron?

A
  • dendrites
  • cell body
  • axon
  • axon terminals
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

where do input signals enter the neuron?

A

dendrites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where do output signals leave the neuron?

A

the axon terminals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

name different types of neuron?

A
  • Purkinje cell (cerebellum)
  • Spinal interneuron
  • Sensory neuron (dorsal root)
  • Pyramidal cell (cerebral cortex)
  • Motor neuron (spinal cord)
  • Bipolar cell (retina)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is a membrane potential?

A

potential difference across the cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

with membrane potential, is the inside or outside of the cell more negative?

A

inside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the range of the membrane potential?

A

20-90mV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is a word to describe the membrane in regard to membrane potential?

A

polarised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what determines the resting membrane potential?

A
  • diffusion of K+ from cell interior through K+ channels
  • the sodium potassium pump also contributes by moving unequal amounts of Na & K (3 Na+ out / 2 K+ in)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what could alter the membrane potential?

A

applying an electric current (stimulus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what could alter the membrane potential?

A

applying an electric current (stimulus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what does hyperpolarisation do to the membrane potential?

A

moves it away from 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does depolarisation do to the membrane potential?

A

moves it closer to 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what happens if membrane potential overshoots 0?

A

the polarisation is reversed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is an action potential?

A

occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize- it is an all or none event

16
Q

describe the sequence of an action potential

A
  • AP is all or none, amplitude is independent of stimulus
    At ‘threshold’:
  • voltage-gated Na+ channels open
  • Na+ diffuse in  depolarisation
    ‘Peak’
  • Na+ channels close
  • voltage-gated K+ channels open
  • K+ diffuse out  repolarisation
    Resting membrane potential
17
Q

how does local anaesthetic work?

A

stops nerve conduction by blocking Na+ channel

18
Q

how does local anaesthetic work?

A

stops nerve conduction by blocking Na+ channel

19
Q

what is the refractory period?

A
  • After an AP is initiated, the neuron cannot generate another AP until the first one has ended
  • This period of inexcitability is called the refractory period
  • It is due to the inactivation of voltage-gated sodium channels
  • Action potentials cannot add together; they are all-or-none events
20
Q

how is an action potential propagated?

A
  • An AP in one section of axon depolarises adjacent ‘resting’ parts of the axon
  • The AP is regenerated further along the axon
  • Action potentials travel along the axon as waves of depolarisation
21
Q

action potentials travel along the length of the axon, but why does it not travel back along the axon?

A

the refractory period

22
Q

what increases when the diameter of the axon increases?

A

the speed of the action potential propagation

23
Q

describe giant axons

A
  • Their speed of AP propagation is too slow to enable the fast postural reflexes present in vertebrates
  • Vertebrates evolved a means of increases AP conduction speed, whilst decreasing axon diameter
24
Q

what is myelination in relation to action protection?

A
  • Wrapping a layer of myelin round an axon greatly increases the AP conduction speed
  • Maximum speed of conduction = 120m.s-1
25
Q

what does myelination do?

A
  • Myelin is a fatty layer
  • Formed by wrapping the membranes of ‘glial’ cells round the axon
  • This in effect ‘insulates’ the axon, and improves conduction
26
Q

what are nodes of ranvier?

A
  • The myelin sheath is interrupted at intervals by ‘nodes of Ranvier’
  • Here, the axon membrane is exposed to the ECF, and ion flow can occur
27
Q

what is saltatory conduction?

A

the way an electrical impulse (action potential) skips from node to node down the full length of an axon