Neuromuscular and Synaptic Transmission Flashcards
[supporting cell]
tissue macrophage in the brain
microglia
[supporting cell]
myelin formation
oligodendrocyte
schwann cell
[supporting cell]
envelope synapses, helps form the BBB
astrocyte
[supporting cell]
astrocyte in the white matter
fibrous astrocyte
[supporting cell]
astrocytes in the gray matter with granular cytoplasm
protoplasmic astrocyte
[supporting cell]
maintain appropriate concentration of ions and NT
protoplasmic astrocyte
[parts of the neuron]
receiving portion
dendrite
[parts of the neuron]
initial segment; AP is generated
axon hillock
[parts of the neuron]
transmitting portion
has unmyelinated or myelinated
axon
[parts of the neuron]
unmyelinated, transmit electrical signal
nodes of ranvier
[parts of the neuron]
tip of axon
terminal buoton
[parts of the neuron]
part of the neuron that is a voltage gated Ca channel
terminal buoton
[parts of the neuron]
where organelles and nucleus are seen
cell body (soma)
[parts of the neuron]
unmyelinated portion of the axon
nodes of ranvier
[parts of the neuron]
branch of the axon
neural fibril
synaptic transmission is __ (orthodromic or antidromic)
orthodromic
[synaptic transmission]
synapse to axon transmission
orthodromic
[synaptic transmission]
axon to synapse transmission
antidromic
[synaptic transmission]
depolarizes postsynaptic cell, brings closer to threshold
EPSP
[synaptic transmission]
hyperpolarizes post synaptic cells due to Cl influx
IPSP
___ summation
2 or more excitatory inputs at rapid succession
Temporal
___ summation
2 or more excitatory inputs at the same time
spatial
[synaptic transmission]
endplate potential is caused by ___ influx
sodium
[synaptic transmission]
____ is caused by Cl influx, K efflux, closure of Na or Ca
IPSP
[synaptic transmission]
___ is caused by Na influx, Ca Influx
Fast EPSP
[synaptic transmission]
___ is caused by K efflux
Slow EPSP
[synaptic transmission]
___ is caused by K efflux
presynaptic inhibition
examples of small molecules NTs
monoamines, catecholamines, amino acids
Examples of large molecules
neuropeptides (substance P, enkephalin, vasopressin)
[neurotransmitter]
triggers REM sleep
acetylcholine
[neurotransmitter]
decreased levels in huntington’s, alzheimer’s dementia
acetylcholine
[neurotransmitter]
found in the the locus ceruleus of pons
norepinephrine
[neurotransmitter]
neuroMODULATOR in the CNS
neuroTRANSMITTER in the PNS
norepinephrine
[neurotransmitter]
the half life is shorter compared to renin, aldosterone, corticosterone, and DHEA
norepinephrine
[neurotransmitter]
primary NT from post-ganglionic sympathetic neurons
norepinephrine
[neurotransmitter]
secreted by the adrenal medulla
epinephrine
[neurotransmitter]
has greater beta 2 action than norepinephrine
epinephrine
[neurotransmitter]
decreases the contraction of airway smooth muscle
epinephrine
[neurotransmitter]
this is secreted to fine-tune movement
dopamine
[neurotransmitter]
action of dopamine in D1 receptor
activate adenylate cyclase
[neurotransmitter]
action of dopamine in D2 receptor
inhibit adenylate cyclase
increase in D2 can lead to
Schizophrenia
[neurotransmitter]
produced in the median raphe of the brain stem
serotonin
[neurotransmitter]
converted to melatonin
serotonin
[neurotransmitter]
associated with depression
serotonin
[neurotransmitter]
inhibitory NT, vasodilator
nitric oxide
[neurotransmitter]
has arginine to citrulline as precursor
nitric oxide
[neurotransmitter]
___ is degraded before reuptake takes place
Ach
[neurotransmitter]
dopamine in substantia nigra ___ movement
modulates
[neurotransmitter]
dopamine in the hypothalamis ____ prolactin
inhibit
[neurotransmitter]
main inhibitory NT of spinal cord
glycine
[neurotransmitter]
main inhibitory NT of brain
GABA, glutamate
[neurotransmitter]
GABAa increases ___ influx
Chloride
[neurotransmitter]
GABAb increases ___ efflux
Potassium
[neurotransmitter]
activates NMDA receptor
glutamate
[neurotransmitter]
formed by the reactive amination of alpha ketoglutarate
glutamate
[neurotransmitter]
inhibits pain perception
opioid peptide
[neurotransmitter]
involved in fast pain and slow pain
glutamate
substance P
[neurotransmitter]
locus ceruleus produces
NE
[neurotransmitter]
phenylalanine derivatives
Phenylalanine Tyrosine L-dopamine Dopamine Norepinephrine Epinephrine T3/T4 Melanin
Pare True Love Does Noe Exist To Me
[neurotransmitter receptors]
Metabotropic receptors utilizes these second messengers
IP3/DAG or cAMP
[neurotransmitter receptors]
Examples of metabotropic receptor
GABAb, neurokinin, opioid receptor
[neurotransmitter receptors]
examples of ion-channel linked receptor
GABAa, nicotinic receptor, NMDA receptor, Glycine receptor, ANP receptor, 5HT3 receptor
[neurotransmitter receptors]
Ligand of GABAa
Cl
[neurotransmitter receptors]
Ligand of nicotinic receptor
Na, K
[neurotransmitter receptors]
Ligand of NMDA receptor
Ca
[neurotransmitter receptors]
Ligand of glycine receptor
Cl
[neurotransmitter receptors]
analgesia, diuresis, sedation, meiosis, dysphoria
kappa
[neurotransmitter receptors]
site of action of morphone
Mu receptor
[neurotransmitter receptors]
analgesia, respiratory depression, constipation, euphoria, sedation, meiosis, increased GH, prolactin
Mu
[neurotransmitter receptors]
highest affinity for Mu receptors
endorphin
[neurotransmitter receptors]
highest affinity for kappa receptors
enkephalin
[neurotransmitter receptors]
highest affinity for delta receptors
dynorphin