NAFLD

Question 1

Pathophysiology?

Answer 1

1. Non-alcoholic fatty liver disease
2. Non-alcoholic steatohepatitis
3. Fibrosis
4. Cirrhosis

Question 2

Aetiology?

Answer 2

fat deposited in liver cells which interferes with liver cells’ functioning

Question 3

Ix?

Answer 3

• abnormal LFTs with no clear cause –> non-invasive liver screen

1. ELF blood test (to assess fibrosis once NAFLD diagnosis reached)
2. NAFLD fibrosis score where ELF not available
3. Fibroscan

Question 4

Diagnosis?

Answer 4

ELF:

• <7.7 –> no to mild fibrosis
• 7.7-9.8 –> moderate fibrosis
• >9.8–> severe fibrosis

Question 5

Mx?

Answer 5

• wt loss
• exercise
• cut smoking and alcohol
• control of DM, BP etc
• refer to hepatologist

Question 6

complications?

Answer 6

increases risk of stroke, MI & DM