Liver - Investigations Flashcards
1
Q
when are aminotransferases raised?
A
with liver damage / liver failure
markers of liver cell damage
2
Q
when is alkaline phosphatase raised?
A
elevated w bile duct obstruction or liver infiltration ie cholestasis
3
Q
when is LDH raised?
A
liver mets & obstructive jaundice
4
Q
when is GGT raised?
A
hepatocellular, hepatobiliary & alcoholic liver disease
5
Q
what tests are done for synthetic function of the liver?
A
- coagulation
- clotting factors 1,2,5,7, 11-13
- monitored using PT/INR
- albumin
6
Q
imaging tests for liver?
A
- USS
- CT
- MRI
- Angiography
- delineates vascular supply to liver
- Nuclear medicine
7
Q
what can USS comment on?
A
- echogenicity
- nodularity
- lesions
- biliary system
- differentiates extrahepatic and intrahepatic obstruction
8
Q
what tests are done in non-invasive liver screen?
A
- Hep B and C serology
- Auto-antibody & serum immunoglobulins
- CMV & EBV
- Caeruloplasmin and copper
- ferritin and transferrin saturation
- alpha 1 antitrypsin
- AFP
- fasting glucose and lipid profile
- US liver
9
Q
what anti-bodies are tested for?
A
autoimmune hepatitis, PBC, PSC:
- ANA
- smooth muscle antibody
- anti-mitochondrial antibodies
- antibodies to LKM-1
