Mutations Flashcards

1
Q

Mutations

A

Changes in the base sequence of A GENE’S DNA that lead to formation of a new allele

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2
Q

How does a mutation lead to change in polypeptide?

A

Change in base sequence of gene’s DNA
Change in primary structure of polypeptide
Alters position of hydrogen bonds/ ionic bonds/ disulfide bridges
Change in tertiary structure of polypeptide

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3
Q

All types of mutation

A

Addition
deletion
substitution
inversion
duplication
translocation

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4
Q

Addition mutation

A

Addition of new base(s) to a gene’s DNA base sequence

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5
Q

Deletion mutation

A

Deletion of bases from a gene’s DNA base sequence

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6
Q

Substitution mutation

A

Switching one base for another in a gene’s DNA base sequence

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7
Q

Inversion mutation

A

Reversing base sequence of a gene’s DNA

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8
Q

Duplication mutation

A

Repeating of a base sequence in a gene’s DNA base sequence

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9
Q

Translocation mutation

A

A base sequence is moved from one locus on a DNA molecule to another DNA locus, on the same chromosome or on a different chromosome

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10
Q

When does translocation mutation usually occur?

A

During mistakes in crossing over in meiosis: mutated gametes more likely than body cells

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11
Q

Do mutations occur randomly?

A

Yes

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12
Q

Can you predict where mutations usually occur?

A

No

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13
Q

Effect of mutations on the organism can be….

A

Good
Bad
Neutral
Completely random which one

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14
Q

Spontaneous mutations

A

Happen most in naturally occurring processes eg DNA replication, meiosis
Randomly occur with no known cause

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15
Q

Mutagenic agents

A

Factors that increase the rate that random mutations can occur at

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16
Q

Where do gene mutations originate in?

A

DNA’s triplets of bases
Affects codons of bases on mRNA thus polypeptide’s amino acid sequence

17
Q

Why do mutations in DNA matter more than in transcribed mRNA

A

Because this mutated DNA will transcribe mRNA and effect ALL polypeptides translated from this gene
And this mutated gene will be passed onto offspring

18
Q

Degenerate

A

Most amino acids can be encoded for by more than one base triplet

19
Q

Are substitution mutations likely to affect sequence of AA on polypeptide?

A

No because genetic code is degenerate so likely the substituted base that results in a new triplet will still encode for same amino acid: no change in primary structure: no change in H/ionic/disulfide bonds: no change in tertiary structure

20
Q

Frameshift

A

Describes mutations that change the nature of base triplets downstream of the mutation
So change amino acid sequence in the polypeptide from the mutation

21
Q

Examples of frameshift mutation

A

Addition
Deletion

22
Q

How can a mutation have no effect on an individual?

A

Mutation occurred in intron/non coding sequence of DNA base sequence so will not affect translation (spliced out of mRNA)
Occurred in a recessive allele of this gene so not expressed in phenotype
Occurs at point in polypeptide that does not change tertiary structure
Substitution base = diff triplet that encodes for same AA

23
Q

How can a mutation have a positive effect on an individual?

A

Changes polypeptide due to change in AA sequence that positively changes properties of protein
Which leads to increased survival chance and increased reproductive success

24
Q

How can a mutation have a negative effect on an individual?

A

Changes polypeptide sequence due to change in AA sequence that negatively changes properties of protein
Leads to decreased survival chance and decreased reproductive success

25
Q

Chromosome mutation

A

Changes in number or structure of chromosomesH

26
Q

How do chromosome mutations differ from gene mutations/

A

Gene mutations occur within specific base sequence in a gene in a chromosome
Chromosome mutations occur during meiosis in the number of chromosomes in each cell

27
Q

Example of chromosome mutation

A

Chromosome non disjunction

28
Q

Chromosome non disjunction

A

Failure of homologous chromosomes/sister chromatids to separate properly during meiosis
So one gamete ends up with too many copies of the same chromosome

29
Q

Non disjunction in meiosis 1 results

A

Homologous chromosomes don’t separate
So when sister chromatids separate in meiosis 2:
2 gametes produced that lack this chromosome
2 gametes produced that have double this chromosome as non sister chromatids both enter gamete (homologous) but sister chromatids have separated so we have 2

30
Q

Non disjunction in meiosis 2 results

A

Homologous chromosomes separate as normal
meiosis 2 means no separation of sister chromatids in one of the daughter cells of meiosis 1
so 1 gamete has 2 copies of same chromosome and 1 gamete does not have this chromosome

31
Q

What causes chromosome non disjunction?

A

Spindle fibre failure to separate sister chromatids or homologous chromosomes