Multiple Sclerosis

Question 1

MS is an autoimmune disease in which its target is the

Answer 1

central nervous system myelin

Question 2

does demyelination occurs in both white matter and gray matter?

Answer 2

Yas

Question 3

_____ matter demyelination contributes to cognitive symptoms

Answer 3

gray

Question 4

does MRI show cortical demyelination?

Answer 4

yes

Question 5

MS have more a ______ state

Answer 5

pro-inflammatory state (adaptive immune system)

Question 6

cool fact about how people get MS?

Answer 6

being/living higher than the equator

Vitamin D?

Question 7

what happens after relapsing?

Answer 7

slow progressive symptoms

Question 8

first clinical indication of MS dx.

Answer 8

MRI lesion

Question 9

in relapsing stage what happens to symptoms?

Answer 9

new symptoms develop frequently and more MRI lesions develop

Question 10

secondary progressive stage

Answer 10

new symptoms are less but old symptoms get worse

Question 11

tx effective only in

Answer 11

during cases were pt. are still having relapsing events

Question 12

MS relapse vs other neurological symptom

Answer 12

acutely progressive neurological symptom generally lasting 24 hr. or more

Question 13

Lumbar puncture might show ______, _______ and WBCs >/< 50 for those with MS

Answer 13

oligoclonal bands, increases IgG synthesis and WBCs < 50

Question 14

what is highly suggestive of MS in MRI findings?

Answer 14

White streaks near the corpus collosum

white marked lesions

Question 15

T1 black holes

Answer 15

more of them, more of them correlates with the progression of the dx.

Question 16

prognosis from early tx. vs delayed vs no tx.

Answer 16

marked differences; no tx. results in huge problems later in life

Question 17

MS tx. is a

Answer 17

disease modifying therapy; not symptom based but putting breaks on the disease

Question 18

older medications for MS

Answer 18

injectable

Question 19

9 ys ago a new form of tx developed

Answer 19

pill based with better efficacy

Question 20

newer tx for MS

Answer 20

monoclonal through IV; works very well

Question 21

possible future medications

Answer 21

those that myelate the demyelated

Question 22

Devic’s Neuromyelitis optica spectrum

Answer 22

acute/Subacute myelitis with optic neuritis

Question 23

Devic’s lesions occur in

Answer 23

hypothlamus and Brainstem

Question 24

NMO antibodies against

Answer 24

Aquaporin -4

Question 25

which dx has a poor prognosis with tendency to relapse

Answer 25

Devic’s

Question 26

NMO long spinal cord lesions with involvment of gray matter near the

Answer 26

4th ventricle

Question 27

You do not see oligoclonal band in NMO

Answer 27

true

Question 28

NMO responds to tx. with

Answer 28

rituxan

Question 29

Can some MS tx. worsen NMO?

Answer 29

yas