Mixed 16

Question 1

What is the MOA of fibrates? How do they promote gallstone formation?

Answer 1

> MOA: upregulates LPL and dec VLDL production, inc HDL prodn by stimulating PPAR-alpha.
It can also inhibit 7-alpha hydroxylase, w/c dec. bile acid synthesis and thus inc. stone formation.

Question 2

What is the DOC for opioid withdrawal?

Answer 2

Methadone is a long-acting mu-receptor agonist with good bioavailabilty. It suppresses cravings and withdrawal ssx.

Question 3

What is the presentation for arsenic poisoning? Treatment?

Answer 3

Arsenic presents with abdominal pain, vomiting, severe watery diarrhea, hypotension (dehydration), and garlic odor on the breath. Treatment is Dimercaprol.

Question 4

How does idiopathic intracranial HTN (pseudotumor cerebri) present?

Answer 4

Usually, in young obese women w/ daily headache, bilateral papilledema, and transient visual disturbances due to compression of the optic nerves.