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IMMUNOSEROLOGY > MHC class > Flashcards

MHC class Flashcards

1
Q

MHC gene location

A

Chromosome 6, short arm, band 21

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2
Q

MHC function

A

Controls tissue compatibility

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3
Q

HLA in humans

A

Human Leukocyte Antigen complex

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4
Q

MHC Class I antigen presentation

A

Endogenous antigens to CD8+ T-cells

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5
Q

Highest MHC Class I expression

A

Lymphocytes and myeloid cells

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6
Q

Low MHC Class I expression

A

Liver hepatocytes, muscle cells, sperm

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7
Q

MHC Class I genetic loci

A

HLA A, B, C

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8
Q

MHC Class I structure

A

Alpha chain, beta-2 microglobulin

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9
Q

MHC Class II restriction

A

Immunocompetent immune cells

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10
Q

MHC Class II antigen presentation

A

Exogenous antigens to CD4+ T-cells

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11
Q

MHC Class II genetic loci

A

HLA-DP, DQ, DR

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12
Q

MHC Class II structure

A

Alpha chain, beta chain

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13
Q

MHC Class II expression

A

B cells, T cells (Class I only)

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14
Q

MHC Class III

A

Involves complement proteins

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15
Q

Complement proteins in MHC III

A

C2, C4a, C4b, Factor B, TNF

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16
Q

Class I MHC function

A

Watchdog for viral, tumor, parasitic antigens

17
Q

Class II MHC function

A

Mount immune response to bacteria or external pathogens

18
Q

HLA Typing purpose

A

Identify HLA antigens/genes in transplant candidates/donors

19
Q

HLA Class I Typing

A

T and B lymphocytes

20
Q

HLA Class II Typing

A

B lymphocytes

21
Q

HLA Phenotyping principle

A

Complement dependent cytotoxicity

22
Q

HLA Phenotyping steps

A

Add antisera to lymphocytes, incubate, add complement, observe lysis

23
Q

HLA Phenotyping grading

A

Grade 1: 0-10% (negative), Grade 8: 81-100% (strong positive)

24
Q

Colored result in HLA Phenotyping

A

Dead cells (lysis)

25
Q

Colorless result in HLA Phenotyping

A

Live cells (no lysis, negative)

26
Q

HLA Genotyping principle

A

PCR-based amplification

27
Q

Importance of HLA typing for organ transplant

A

Tissue/organ transplant

28
Q

Immunosuppressive agent that blocks production and secretion of cytokines

A

Corticosteroids

29
Q

Immunosuppressive agent that interferes with lymphocyte maturation

A

Antimetabolites

30
Q

Immunosuppressive agent that blocks signal transduction in T lymphocytes

A

Calcineurin inhibitors

31
Q

Immunosuppressive monoclonal antibody binding CD25 receptor

A

Basiliximab and daclizumab

32
Q

Immunosuppressive monoclonal antibody binding CD52 receptor

A

Alemtuzumab

33
Q

Polyclonal antibody that depletes lymphocytes from circulation

A

Thymoglobulin

IMMUNOSEROLOGY (22 decks)

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