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IMMUNOSEROLOGY > Markers and Disease associated > Flashcards

Markers and Disease associated Flashcards

1
Q

Gene marker associated with ankylosing spondylitis

A

HLA-B27

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2
Q

Gene marker associated with multiple sclerosis

A

HLA-DR3

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3
Q

Gene marker associated with systemic lupus erythematosus (SLE)

A

HLA-DR2, HLA-DR3

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4
Q

Gene marker associated with rheumatoid arthritis (RA)

A

HLA-DR4

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5
Q

Gene markers associated with Type I diabetes mellitus

A

HLA-DR3, HLA-DR4

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6
Q

Complement deficiency associated with lupus-like syndrome and recurrent infections

A

C1, C2, C4

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7
Q

Complement deficiency associated with severe recurrent infections and glomerulonephritis

A

C3

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8
Q

Complement deficiencies associated with recurrent Neisseria infections

A

C5, C6, C7, C8, Properdin

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9
Q

Complement component linked to hereditary angioedema

A

C1 Inhibitor (C1-INH)

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10
Q

Complement regulatory protein deficiencies causing Paroxysmal Nocturnal Hemoglobinuria

A

DAF and/or MIRL

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11
Q

Deficiencies in Factor H or I result in

A

Recurrent pyogenic infections

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12
Q

Enzyme marker associated with liver cancer

A

Alcohol dehydrogenase, Aldolase

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13
Q

Enzyme marker associated with bone, liver, and leukemia-related cancers

A

Alkaline phosphatase

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14
Q

Enzyme marker associated with prostate cancer

A

Prostatic Acid Phosphatase

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15
Q

Enzyme marker associated with small cell lung cancer, neuroblastoma, and melanoma

A

Neuron Specific Enolase

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16
Q

Enzyme marker associated with lymphoma and leukemia

A

Lactate Dehydrogenase

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17
Q

Hormone marker linked to Cushing’s syndrome and lung cancer

A

ACTH

18
Q

Hormone marker linked to lung, adrenal cortex, and pancreatic cancers

A

ADH

19
Q

Hormone marker linked to medullary thyroid cancer

A

Calcitonin

20
Q

Hormone marker linked to pheochromocytoma and neuroblastoma

A

Vasoactive Intestinal Peptide

21
Q

Hormone marker linked to choriocarcinoma and embryonal cancers

A

Human Chorionic Gonadotropin (hCG)

22
Q

Oncofetal antigen marker associated with hepatocellular and germ cell tumors

A

AFP

23
Q

Oncofetal antigen marker associated with liver cancer

A

Carcinofetal ferritin

24
Q

Oncofetal antigen marker associated with colorectal, gastrointestinal, lung, breast, and pancreatic cancers

A

CEA

25
Q

Oncofetal antigen marker associated with cervical, lung, skin, and head & neck cancers

A

Squamous Cell Antigen

26
Q

Oncofetal antigen marker associated with colon, gastrointestinal, and bladder cancers

A

Tennessee Antigen

27
Q

Marker linked to breast, colorectal, ovarian, and bladder cancers

A

Cytokeratins (Tissue Polypeptide Antigen)

28
Q

Prognostic marker for non-small cell lung cancer

A

CYFRA-21-1 (Cytokeratin 19 Fragments)

29
Q

Tumor marker associated with multiple myeloma, CML, and Waldenstrom’s macroglobulinemia

A

Beta-2 Microglobulin

30
Q

Tumor marker associated with insulinoma

A

C-Peptide

31
Q

Tumor marker associated with liver, lung, breast cancers, and leukemia

A

Ferritin

32
Q

Tumor marker associated with multiple myeloma and lymphomas

A

Immunoglobulins

33
Q

Tumor marker specifically associated with melanoma

A

Melanoma Associated Antigen

34
Q

Tumor marker associated with hepatocellular carcinoma

A

Des-gamma Carboxy Prothrombin

35
Q

Tumor marker associated with mesothelioma and ovarian cancers

A

Soluble Mesothelin Related Peptides

36
Q

Tumor marker associated with ovarian and endometrial cancers

A

CA-125

37
Q

Tumor marker associated with breast and ovarian cancers

A

CA-15-3, CA-549, MUCIN-Like Carcinoma Associated Antigen (MCA)

38
Q

Tumor marker associated with pancreatic cancer

A

CA-19-9 (Best marker), CA-19-5, CA50, CA242

39
Q

Tumor marker associated with newer tests for ovarian, pancreatic, and stomach cancers

A

CA 72-4

40
Q

Oncogenes associated with breast cancer

A

HER-2/NEU (ERBB2), BRCA1 (chromosome 17q)

IMMUNOSEROLOGY (22 decks)

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