Markers and Disease associated Flashcards
Gene marker associated with ankylosing spondylitis
HLA-B27
Gene marker associated with multiple sclerosis
HLA-DR3
Gene marker associated with systemic lupus erythematosus (SLE)
HLA-DR2, HLA-DR3
Gene marker associated with rheumatoid arthritis (RA)
HLA-DR4
Gene markers associated with Type I diabetes mellitus
HLA-DR3, HLA-DR4
Complement deficiency associated with lupus-like syndrome and recurrent infections
C1, C2, C4
Complement deficiency associated with severe recurrent infections and glomerulonephritis
C3
Complement deficiencies associated with recurrent Neisseria infections
C5, C6, C7, C8, Properdin
Complement component linked to hereditary angioedema
C1 Inhibitor (C1-INH)
Complement regulatory protein deficiencies causing Paroxysmal Nocturnal Hemoglobinuria
DAF and/or MIRL
Deficiencies in Factor H or I result in
Recurrent pyogenic infections
Enzyme marker associated with liver cancer
Alcohol dehydrogenase, Aldolase
Enzyme marker associated with bone, liver, and leukemia-related cancers
Alkaline phosphatase
Enzyme marker associated with prostate cancer
Prostatic Acid Phosphatase
Enzyme marker associated with small cell lung cancer, neuroblastoma, and melanoma
Neuron Specific Enolase
Enzyme marker associated with lymphoma and leukemia
Lactate Dehydrogenase
Hormone marker linked to Cushing’s syndrome and lung cancer
ACTH
Hormone marker linked to lung, adrenal cortex, and pancreatic cancers
ADH
Hormone marker linked to medullary thyroid cancer
Calcitonin
Hormone marker linked to pheochromocytoma and neuroblastoma
Vasoactive Intestinal Peptide
Hormone marker linked to choriocarcinoma and embryonal cancers
Human Chorionic Gonadotropin (hCG)
Oncofetal antigen marker associated with hepatocellular and germ cell tumors
AFP
Oncofetal antigen marker associated with liver cancer
Carcinofetal ferritin
Oncofetal antigen marker associated with colorectal, gastrointestinal, lung, breast, and pancreatic cancers
CEA
Oncofetal antigen marker associated with cervical, lung, skin, and head & neck cancers
Squamous Cell Antigen
Oncofetal antigen marker associated with colon, gastrointestinal, and bladder cancers
Tennessee Antigen
Marker linked to breast, colorectal, ovarian, and bladder cancers
Cytokeratins (Tissue Polypeptide Antigen)
Prognostic marker for non-small cell lung cancer
CYFRA-21-1 (Cytokeratin 19 Fragments)
Tumor marker associated with multiple myeloma, CML, and Waldenstrom’s macroglobulinemia
Beta-2 Microglobulin
Tumor marker associated with insulinoma
C-Peptide
Tumor marker associated with liver, lung, breast cancers, and leukemia
Ferritin
Tumor marker associated with multiple myeloma and lymphomas
Immunoglobulins
Tumor marker specifically associated with melanoma
Melanoma Associated Antigen
Tumor marker associated with hepatocellular carcinoma
Des-gamma Carboxy Prothrombin
Tumor marker associated with mesothelioma and ovarian cancers
Soluble Mesothelin Related Peptides
Tumor marker associated with ovarian and endometrial cancers
CA-125
Tumor marker associated with breast and ovarian cancers
CA-15-3, CA-549, MUCIN-Like Carcinoma Associated Antigen (MCA)
Tumor marker associated with pancreatic cancer
CA-19-9 (Best marker), CA-19-5, CA50, CA242
Tumor marker associated with newer tests for ovarian, pancreatic, and stomach cancers
CA 72-4
Oncogenes associated with breast cancer
HER-2/NEU (ERBB2), BRCA1 (chromosome 17q)