Hypersensitivity

Question 1

What is hypersensitivity?

Answer 1

Heightened immune responsiveness against harmless antigens

Question 2

Test is preferred for skin testing in immediate hypersensitivity?

Answer 2

Percutaneous (prick method)

Question 3

Positive skin test result identified?

Answer 3

Wheal and flare (redness and swelling)

Question 4

In vitro test for total serum IgE?

Answer 4

Radioimmunosorbent Test (RIST)

Question 5

Purpose of RAST test?

Answer 5

Measures specific IgE antibodies

Question 6

Primary mediators of Type I hypersensitivity?

Answer 6

Histamine, Heparin, Eosinophil Chemotactic Factor (ECF-A), Neutrophil Chemotactic Factor (NCF-A)

Question 7

Secondary mediators of Type I hypersensitivity?

Answer 7

Prostaglandins, Leukotrienes, Platelet Activating Factor, IL-1, IL-3, IL-4

Question 8

Cells involved in degranulation for Type I hypersensitivity

Answer 8

Mast cells and basophils

Question 9

Type II hypersensitivity is mediated by

Answer 9

Antibodies against antigens on cell surface causing cytolysis

Question 10

Type III hypersensitivity involves

Answer 10

Soluble antigens and the deposition of Ag-Ab complexes in tissues

Question 11

Type IV hypersensitivity is mediated by

Answer 11

T-cells

Question 12

Type of hypersensitivity involving Hemolytic Transfusion Reactions (HTR), Autoimmune Hemolytic Anemia (AIHA), Paroxysmal Cold Hemoglobinuria (PCH), Cold Agglutinins

Answer 12

Type II hypersensitivity

Question 13

Tests for Type II hypersensitivity

Answer 13

Direct and Indirect Antihuman Globulin (AHG) test

Question 14

Test for Type III hypersensitivity

Answer 14

Labelled immunoassays

Question 15

Type IV hypersensitivity is mediated by

Answer 15

T-cells

Question 16

Antigens involved in Type IV hypersensitivity

Answer 16

Intracellular pathogens (bacteria, fungi, parasites, viruses), Contact antigens (poison ivy, metal)

Question 17

Confirmatory test for contact dermatitis in Type IV hypersensitivity

Answer 17

Patch test

Question 18

Type I hypersensitivity involves

Answer 18

Antibody production

Question 19

Type IV hypersensitivity involves

Answer 19

T-cell memory and Ab specificity

Question 20

Tuberculin test result for Type IV hypersensitivity

Answer 20

NTP > 10 mm (+) or > 15 mm

Question 21

Type I, II, III are mediated by

Answer 21

Antibodies

Question 22

Type of hypersensitivity involving: Anaphylaxis, hay fever, food allergies, asthma

Answer 22

Type I

Question 23

Type of hypersensitivity: Transfusion reactions, autoimmune hemolytic anemia, hemolytic disease of newborn, thrombocytopenia

Answer 23

Type II

Question 24

Type of hypersensitivity: Serum Sickness, Arthus reaction, Systemic Lupus Erythematosus

Answer 24

Type III

Question 25

Type of hypersensitivity: Contact dermatitis, tuberculin test, pneumonitis, allergy or infection

Answer 25

Type IV

Question 26

Types of hypersensitivity that are antibody mediated

Answer 26

Type I, II, III

Question 27

Type of hypersensitivity that is cellular mediated

Answer 27

Type IV

Question 28

Immune component involved in Type II and III hypersensitivity

Answer 28

Complement