MedEd diabetes and pituitary Flashcards
What gene is T1DM associated with?
HLA DR3/4
What is T2DM associated with?
Obesity
HTN
Inactivity
Dyslipidaemia
What state causes polyuria in T1DM?
Osmotic diuresis
What are some signs of DKA?
Nausea and vomitting
Abdo pain
Kaussmal breathing
What are some signs of T2DM?
Acanthosis nigricans
Signs of peripheral disease/ complications
What is random glucose in diabetes?
> 11.1
What is fasting glucose in diabetes?
> 7
What is HbA1c in diabetes?
> 48
What antibodies are associated with T1DM?
Anti GAD antibodies
Islet cell antibodies
What test should you always do for T1DM in GP and what will you see?
Urine dip- positive glucose and ketones
How is insulin given in T1DM?
Basal bolus regimen
What is the first line treatment for T2DM?
Lifestyle advice= diet, exercise, education
What is the first line pharmacological treatment for glycaemic control in T2DM?
Metformin
What is the first line pharmacological treatment for blood pressure management in T2DM? What is second and third line
Ace inhibitor, if black ARB
Then add CCB or thiazide
Then ACEi/ARB with CCB and thiazide
What glucose level is classed as hypoglycaemia?
<3.6 mmol/L
What are signs of hypoglycaemia?
Palpitations, tremors, sweating, pallor, anxiety, drowsiness, confusion, coma
How is hypoglycaemia managed?
If conscious- eat sugary food
If consciousness is impaired - IM glucagon 1g
What triad signifies DKA?
Hyperglycaemia
Ketonaemia
Metabolic acidosis
Why is ketonaemia harmful?
Acidity causes enzyme dysfunction which can lead to coma and death
How is DKA managed?
Hydration with IV fluid
Insulin to reduce ketones
What is HHS? How does it present?
Hyperosmolar hyperglycaemic state- hyperglycaemia with no ketonaemia
Dehydration, kussmaul breathing, nausea and vomitting
How can you differentiate DKA and HHS based on signs and symptoms?
They are the same but no abdo pain in HHS
How are DKA and HHS managed?
Start IV saline (and potassium chloride if K+ <5.5)
IV insulin (fixed rate) after fluids (only when K+ is not <3.5)
Include dextrose in fluids if <14
Treat underlying cause eg abx
What is plasma glucose in DKA?
> 11
What is plasma glucose in HHS?
> 30
What are the 4 stages of retinopathy?
1= background retinopathy= blot and dot haemorrhage/ hard exudates 2= pre prolif= background and cotton wool spots 3= proliferative= non proliferative and new vessels on disk (neovascularisation) 4= maculopathy= hard exudates and near macular
What is neovascularisation associated with?
Retinal detachment with retinal detachment and vitreoud haemorrhage with visual loss
How is retinopathy managed?
Backgorund= improve glycaemic control
Pre proliferative and proliferative= pan retinal laser photocoagulation
Maculopathy= anti VEGF injections
How does diabetic nephropathy present?
Oedema, polyuria, lethargy, hypertension
What is the first line investigation for diabetic nephropathy? What will you see?
Urinalysis
Will show a high albumin: creatinine due to microalbuminuria