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Year 3 > Gastro conditions > Flashcards

Gastro conditions Flashcards

1
Q

When is it appropriate to refer someone for an upper GI endoscopy in relation to suspicions of gastric/oesophageal cancer?

A

When someone has dysphagia

When someone is over 55 and has new onset dysphagia with weight loss and abdo pain/ reflux/ dyspepsia

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2
Q

What is cholecystitis?

A

Inflammation of the gallbladder

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3
Q

What is the most common case of cholecytsitis?

A

Gallstones

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4
Q

What symptoms will someone with gallstones classically present with?

A

Pain in the RUQ
Palpable mass in RUQ
Positive Murphy’s sign
Signs of inflammation

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5
Q

How do you test for Murphy’s sign, when would you do it and when is it positive?

A

Palpate under the 9th costal cartilage when you suspect gallbladder pathology
On inspiration, the gallbladder will move down and hit your hand causing the pain to be in pain

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6
Q

Who is most likely to get cholecystitis?

A

Those in the western world

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7
Q

What is the first line investigation for cholecystitis?

A

If asymptomatic no investigations are needed
If symptomatic do LFTs and an ultrasound of the biliary tree
If nothing is found on ultrasound and you still suspect gallstones due to a widened biliary tree or deranged LFTs do an MRCP
If MRCP is not conclusive you can do and EUS

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8
Q

How is cholecystitis managed?

A

If the patient is waiting for treatment tell them to avoid foods that trigger their symptoms
Do a laparoscopic cholecystectomy and then a clearance of the bile duct

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9
Q

What are some risks for acute cholecystitis?

A

Having existing gallstones

Having previous episodes of RUQ pain

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10
Q

When someone has gallstones when will their pain characteristically come on?

A

After fatty meals

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11
Q

What is cholangitis?

A

Inflammation of the biliary tree

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12
Q

What is the difference between cholecystitis and cholangitis?

A 
Cholecystitis= inflammation of the gallbladder
Cholangitis= inflammation of the biliary tree
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13
Q

What is pancreatitis?

A

Inflammation of the pancreas

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14
Q

What symptoms will someone with acute pancreatitis present with?

A 
Deep boring pain in the epigastric pain that localises to the LUQ, radiates to the back, is persistent, alleviated by sitting forward or lying on their side, takes 10-20 mins to reach maximal intensity 
Vomiting
Jaundice 
Grey Cullens or Turner's sign
Fever
Tachycardia
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15
Q

What is Grey Cullens and Turner’s sign? When would you see it?

A

Bruising around the flank and umbilicus

Seen in pancreatitis

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16
Q

What is pain in acute pancreatitis characteristically like?

A

Starts in epigastric region
Localises to LUQ
Takes 10-20 mins to reach maximal intensity
Deep and boring
Radiates to back
Alleviated by sitting forwards or lying on the side
Constant

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17
Q

How will a patient with acute pancreatitis lie?

A

Sometimes very still and on their side

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18
Q

What are the first line investigations for acute pancreatitis?

A

LFTs, bloods, serum amylase and lipase
Ultrasound pancreas if you suspect gallstones
MRI if there is persistent organ failure

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19
Q

What are risk factors for pancreatitis?

A

Alcohol use

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20
Q

How is pancreatitis managed?

A

ABC first
Fluid resus
Supportive treatments like oxygen, analgesia, enteral feeding if they are unable to eat
Treat the causes eg remove gallstones surgically if thats the cause

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21
Q

What are complications of acute pancreatitis?

A

ARDs
Systemic complications eg sepsis, shock, renal failure
Necrosis of the pancreas, formation of a pseudocyst or abcess etc

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22
Q

What is it important to note if the suspected cause of pancreatitis is gallstones?

A

They may not be visible on ultrasound if there is inflammation so you may have to wait for a few days

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23
Q

What is an anal fissure?

A

A split in the skin in the distal anal canal

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24
Q

What symptoms will someone with anal fissures classically present with?

A

A tearing pain in the anus on defecation
Burning sensation that lasts 1-2 hours after defecation
Anal spasm
Blood in the stool or when wiping

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25
Q

Who is most likely to get anal fissures?

A

Young adults

Pregnant women

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26
Q

What are some causes of anal fissures?

A 
Cancer
STI
Pregnancy
IBD
Poor toileting 
Opiate analgesia use
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27
Q

What is the first line investigation for anal fissure?

A

None- diagnosis can be clinical and after examination (get them to lie on their side and spread their buttocks but note you may not be able to see it if its superficial or if there is anal spasm)

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28
Q

How are anal fissures managed?

A

If they are constipated treat the constipation
If stool is normal advise a high fibre diet and lots of fluid intake
If not healed in a week offer rectal GTN ointment
If pain is severe offer analgesia or anaesthetics
If you suspect cancer or if its atypical looking, refer to the relevant specialist

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29
Q

What are complications of anal fissures?

A

Chronic fissure
Recurrence
Incontinence after surgery

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30
Q

What is coeliac disease?

A

An autoimmune disorder wherein there is a reaction to dietary gluten peptides that results in villous atrophy and increased lymphocytes etc

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31
Q

What symptoms would someone with coeliac disease classically present with?

A 
Abdominal pain/discomfort/distention
Bloating
Unexplained weight loss
Unexplained anaemia, B12/folate deficiency 
Faltering growth 
Mouth ulcers
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32
Q

What are risk factors for coeliac disease?

A

Genetic/having a first degree relative with it
Having an autoimmune thyroid disorder
Having type 1 diabetes

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33
Q

Who is more likely to get coeliac disease?

A

Women
Those with a first degree relative
People in Europe/US

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34
Q

What is the first line investigation for coeliac disease?

A

Serology- first screen for IgA ttg (they must be eating a diet with gluten in it for 6 weeks leading up to it)
If positive refer to specialist for endoscopy so that it can be confirmed and ruled out

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35
Q

What must be done in prep for serology for coeliac disease?

A

The patient must eat gluten at least in one meal for 6 weeks leading up to the test

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36
Q

How is coeliac disease managed?

A

Refer to a dietician who will teach them about what contains gluten and what doesn’t, how to avoid contamination, food labelling etc

Also offer annual review to check height/weight, review symptoms, check adherence to diet etc

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37
Q

What are haemorrhoids?

A

Naturally occuring vascular tissue in the distal anal canal that becomes pathological

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38
Q

What are the 2 types of haemorrhoids and how do they differ?

A 
Internal= lie proximal to the dentate line in the anal canal
External= lie distal to the dentate line in the anal canal
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39
Q

What symptoms will someone with haemorrhoids classically present with?

A

Perianal pain or discomfort

Bleeding from the anus- in the stool or on wiping

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40
Q

What are some risk factors for developing haemorrhoids?

A

Constipation
Pregnancy
Age 45-65
Presence of a space occupying lesion

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41
Q

How are haemorrhoids managed?

A

They may naturally heal, in the meantime ensure the patient is not constipated, give analgesia and local haemorrhoid ointment
If severe, admit
Surgically remove by doing a haemorrhoidectomy, band ligation etc

42
Q

What is the first line investigation for haemorrhoids?

A

Anal exam
Consider colonoscopy if you suspect other things are wrong
FBC if there has been prolonged bleeding and you suspect anaemia

43
Q

What is diverticular disease?

A

Presence of diverticula with mild abdominal pain or tenderness but no systemic symptoms

44
Q

What symptoms will a someone with diverticular disease present with classically?

A

Intermittent abdominal pain in the left lower quadrant
Pain worse after eating
Pain relieved by passing faeces or flatus
Constipation or diarrhoea
Intermittent rectal bleeding

45
Q

Who is more likely to get diverticular disease?

A

Older people (over 50)
People who aren’t vegetarian
People on a low fibre diet

46
Q

What is the first line investigation for diverticular disease?

A

Bloods: FBC to check anaemia, CRP to check inflammation

Endoscopy or radiography

47
Q

How is diverticular disease managed?

A

Primarily lifestyle advice like high fibre diet (need to do for weeks to see effects), exercise, high fluid intake, avoid NSAIDs and opioid analgesia
Advise paracetamol if they really need pain relief
Antispasmodics if they have stomach cramps

48
Q

How may diverticular disease present differently in asian people? How does this differ to normal presentation

A

It may be right sided instead of left sided

49
Q

What is GORD?

A

Symptoms or complications that arise from the reflux of acid contents from the stomach into the oesophagus or above

50
Q

What symptoms will someone with GORD present with classically?

A

Heartburn
Epigastric pain
Acid regurgitation

They may also have:
Bitter taste in mouth
Asthma 
Cough 
Laryngitis
51
Q

What are some risk factors for developing GORD?

A

Higher BMI/obesity
Family history of acid reflux or heartburn
Drugs that reduce the pressure of the lower oesophageal sphincter
Previous oesophagitis
Hiatus hernia

52
Q

What is the first line investigation for GORD?

A

None- usually diagnosis is clinical and further investigation eg OGD/endoscopy is only needed if treatment doesn’t work or complications eg Barrett’s oesophagus are expected

53
Q

How is GORD managed?

A

4-8 week full dose PPIs

54
Q

What medications have the ending ‘zole’?

A

PPIs

55
Q

What might increase someones risk of Barrett’s oesophagus?

A

Having long term GORD
Having a hiatus hernia
Having previous oesophagitis
Being male

56
Q

What are some complications of GORD?

A

Barrett’s oesophagus
Oesophageal cancer
Stricture

57
Q

What is a hiatus hernia?

A

A protrusion of abdominal contents through a widened hiatus of the diaphragm

58
Q

What symptoms will someone with a hiatus hernia classically present with?

A 
Many are asymptomatic 
Symptoms of GORD= acid regurgitation and heartburn
Dysphagia 
Odynophagia 
Anaemia
Cough
59
Q

Who is more are risk of developing a hiatus hernia?

A

Pregnant women
Those of older age (above 50)
Obese/overweight people

60
Q

What is the first line investigation for hiatus hernia?

A

None- diagnosis can be clinical and further investigations are only needed if there are complications/symptoms are persistent after treatment
Chest x ray
OGD
Bloods- check for anaemia, inflammation

61
Q

How are hiatus hernias managed?

A

If symptoms aren’t bad treatment isn’t needed
PPIs for reflux symptoms
Lifestyle advice like eat smaller meals more frequently, avoid foods that trigger reflux, stop smoking
Surgical repair can be done if symptoms are bad via Nissen fundoplication

62
Q

What surgical procedure is used to repair hiatus hernias?

A

Nissen fundoplication

63
Q

What is a type I hiatus hernia?

A

Sliding- wherein the OGD is above the hiatus of the diaphragm and a portion of the stomach had slid up

64
Q

What is a type II hiatus hernia?

A

Rolling- wherein the OGD is at the normal level but a pouch of the stomach has protruded above the hiatus of the diaphragm

65
Q

What is a type III hiatus hernia?

A

Mixed- wherein the ODG is above the normal levels and a pouch of the stomach has protruded above the hiatus too

66
Q

What is a type IV hiatus hernia?

A

When other organs apart from the stomach protrude above the hiatus of the diaphragm

67
Q

What type of hiatus hernia is most common?

A

Type I

68
Q

What are some complications of hiatus hernia?

A

Strangulation

Obstruction

69
Q

If a hiatus hernia is asymptomatic what should you warn the patient of for when they should go to a&e about it?

A

If it becomes red, hot, swollen or painful ie signs of infection and strangulation

70
Q

What is constipation?

A

Difficulty passing stool

71
Q

What symptoms will someone with constipation present with classically?

A

Difficulty passing stool- trying to defecate for long, having to strain hard
Infrequent passing of stool
Feeling excavation is incomplete

72
Q

Who is more at risk of constipation

A 
Older people (over 65)
Pregnant women
Those with a low fibre diet
Those with a sedentary lifestyle 
Those with low fluid intake
73
Q

What is the first line investigation for constipation?

A

None, most of it is clinical

74
Q

How is constipation managed?

A

Lifestyle advice: high fibre diet, high fluid intake, exercise
Normal constipation: first line bulk forming laxative, second line osmotic laxative, if neither work and constipation is chronic consider prucalopride
Opioid induced constipation: do not give bulk forming laxative, first line osmotic

75
Q

How does treatment for opioid induced constipation differ from treatment for normal constipation?

A

They are not given bulk forming laxatives

76
Q

What are some complications of constipation?

A

Anal fissure
Haemorrhoids
Faecal impaction

77
Q

What is an example of a bulk forming laxative?

A

Isphagula

78
Q

What is an example of an osmotic laxative?

A

Lactulose

Macrogol

79
Q

What is ascending cholangitis?

A

Inflammation/infection and blockage of the CBD that can spread systemically

80
Q

What symptoms will someone with ascending cholangitis classically present with? Explain why each arises

A

Charcot’s triad:
Fever (with rigors)= due to infection
Jaundice= due to blocked flow of bile in CBD
RUQ pain= due to location of gallbladder/CBD

81
Q

What triad of symptoms is associated with ascending cholangitis?

A

Charcot’s= fever, jaundice, RUQ pain

82
Q

What is Charcot’s triad and what is it associated with?

A

It is a triad of symptoms that is typical of someone with ascending cholangitis and includes fever (with rigors), jaundice and RUQ pain

83
Q

What is cholelithiasis?

A

Formation of gallstones

84
Q

What classic symptom will someone with gallstones describe?

A

A sharp, stabbing pain in their RUQ a few hours following fatty meals

85
Q

What is peptic ulcer disease?

A

A break in the mucosal lining of the stomach or duodenum bigger than 5mm and down to te submucosa

86
Q

What are the 2 locations of common ulcers

A 
Duodenum
Stomach (gastric)
87
Q

What symptoms will someone with peptic ulcer classically present with?

A

Burning pain in epigastric region (after meals)
Melaena
High BP

88
Q

What are the risk factors for developing peptic ulcer disease?

A

Being on NSAIDs
Family history
H pylori infection

89
Q

What is the first line investigation for peptic ulcer disease?

A

Upper GI endoscopy

90
Q

What investigations are done for peptic ulcer disease? Explain why?

A

Upper GI endoscopy- to identify the source of bleeding
FBC- to check for anaemia
H pylori breath test- to check if infection by h pylori is the cause of peptic ulcer

91
Q

How is peptic ulcer disease managed?

A

If h pylori positive then h pylori eradication therapy
If h pylori negative then treat the cause (ulcer healing therapy if NSAID induced, if bleeding give them transfusions)- give PPI and 2 antibiotics

92
Q

What is ulcerative colitis?

A

A type inflammatory bowel disease wherein there is disruption to the bowels starting from the rectum and extending proximally upwards to a point in the large colon

93
Q

What symptoms will someone with ulcerative colitis classically present with?

A

Blood in stool
Diarrhoea >6 weeks
Tenesmus- a painful urge to defecate even when you don’t need to
Pain before defecation that is relieved after defecation
Weight loss
Abdominal pain- especially in the left lower quadrant
Uveitis and episcleritis
Erythema nodosum or pyoderma gangrenosum
Apthous mouth ulcers
Pallor
Clubbing

94
Q

What are some extra GI manifestations of UC?

A 
Eyes- uveitis and episcleritis
Mouth- apthous ulcers
Pallor- due to anaemia 
Nails- clubbing 
Skin- erythema nodosum or pyoderma gangrenosum rash
95
Q

Who is more likely to get UC?

A

Those with family history

Those who are HLA B-27 positive

96
Q

What investigations would you do for someone with UC and why?

A

Colonoscopy- to image the colon and see the pattern of bowel disruption
FBC- check for anaemia
U+Es, vitamins etc- check to see if they are malnourished in any way
Faecal calprotectin- WCC in faeces may be raised, it will not be in IBS
Stool culture and microscopy- to rule out c diff infection
Thyroid function tests- to rule out hypothyroidism
Inflammatory markers- ESR and CRP may be raised

97
Q

How is UC managed?

A

First line aminosalicyclates- these are given topically or enema first then orally if needed
If that doesnt work consider immunosupressive drugs or biologics (if multiple episodes of corticosteroids are needed to induce remission in a year)
In an acute flare up give IV corticosteroids
Colectomy may be needed if the disease progresses

98
Q

What are some complications of UC?

A

Haemorrhage
Toxic megacolon
Colonic adenocarcinoma- screen them more regularly
Benign stricture

99
Q

What layer is invasion limited to in UC?

A

Mucosa or submucosa

100
Q

What cell is UC associated with?

A

Th17

101
Q

What part of the colon is affected in UC?

A

The rectum is always affected

Then the large bowel extending proximally in

Year 3 (104 decks)

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