MedEd acute withdrawal Flashcards
What is alcohol withdrawal?
Physiological and physical symptoms that arise when someone with alcohol dependancy stops or reduces alcohol intake within hours or days of presentation
What 2 receptors are involved in alcohol withdrawal? Which is excitatory and which is inhibitory?
NMDA receptors- excitatory
GABA (type A) receptors- inhibitory
Are NMDA receptors excitatory or inhibitory?
Excitatory
Are GABA type a receptors excitatory or inhibitory?
inhibitory
In chronic alcoholism what receptors are upregulated/ downregulated?
NMDA receptors are upregulated
GABA type a are downregulated
In acute alcohol what is the receptor balance?
GABA type a receptors are a lot higher than NMDA
In alcohol withdrawal what is the receptor balance?
NMDA receptors are a lot higher than GABA type a
What are RF for alcohol withdrawal?
Alcohol use disorder
Hx of alcohol withdrawal
Poor physical health
What are signs of chronic or decompensated liver disease? What molecules cause these
High ammonia- encephalopathy
Albumin- causes ascites and peripheral oedema
Bilirubin- causes jaundice
Reduced clotting factors- causes bruising
What is the triad for wernicke’s encephalopathy and what acronym is used to remember?
CAN:
confusion
ataxia
nystagmus
What is deficient in wernicke’s encephalopathy?
B1 and thiamine
What does thiamine and B1 deficiency cause?
Wernicke’s encpehalopathy
What are the 4 stages of alcohol withdrawal over time?
minor withdrawal symptoms
alcoholic hallucinations
withdrawal seizures
withdrawal delirium
As time from presentation progresses what stages of alcohol withdrawal are reached and when?
6-12 hrs= minor withdrawal symptoms
12-24hrs= alcoholic hallucinations
24-48 hrs= withdrawal seizures
48-72 hrs= withdrawal delirium
What are minor alcohol withdrawal symptoms?
Anxiety
Agitation
GI upset
Sweating/tremor
What type of withdrawal seizures occur in alcohol withdrawal?
Generalised tonic clonic seizures
What is seen in withdrawal delirium in alcohol withdrawal?
Delirium tremens
Severe tremor
Fever
High BP and HR
What are differentials for alcohol withdrawal?
Hypoglycaemia
Hepatic encephalopathy
Meningitis
How does hypoglycaemia present?
Tremors Palpitations Anxiety Seizures Drowsiness
How does hepatic encephalopathy present?
tremors anxiety palpitations anxiety seizures
What is the triad for meningitis and what is the limitation of this triad?
Fever
Altered mental status
Nuchal rigidity
not all patients present with nuchal rigidity
What scale is used to assess severity of alcohol withdrawal?
CIWA-AR scale
What ix might you do bedside for alcohol withdrawal and what will you see?
Screening- use CIWA-AR to assess severity
ECG- electrolyte abnormalities cause changes
VBG- resp alkalosis or metabolic acidosis or metabolic alkalosis with a high anion gap
What is seen on bloods for alcohol withdrawal?
Glucose- hypoglycaemia FBC- high MCV, thrombocytopenia UEs- electrolyte deficiency LFT- elevated AST, ALT, GGT Coagulation studies- prolonged INR and PT
How is alcohol withdrawal managed?
Urgent= benzodiazepines, CT head, detect and treat co existing illness
Supportive treatments= rehydrate with IV fluids, pabrinex (vitamin B), glucose if hypoglycaemic, correct electrolyte imbalances
What is pabrinex and when is it given?
it is vitamin b and its given as supportive treatment eg alcohol withdrawal
When treating alcohol withdrawal what is it important to remember when giving glucose?
Only give it after thiamine but dont delay if hypoglycaemia is life threatening
What can you refer patients to for long term underlying alcohol dependance?
DALs, community services, therapy
How will someone with alcohol dependance present?- include the signs of which 2 conditions
Signs of chronic liver failure- jaundice, ascites/peripheral oedema, bruising
Signs of Wernicke’s encephalopathy- confusion, ataxia, nystagmus