MedEd derm Flashcards
when describing lesions what are the 3 types?
flat
fluid filled
raised
what are the types of flat skin lesions and how do they differ?
macule= small patch= large
what are the types of fluid filled skin lesions and how do they differ?
vesicle= small ie <0.5cm diameter bulla= large ie >0.5cm diameter pustule= pus filled
what are the types of raised skin lesions and how do they differ?
papule= small ie <0.5cm in diameter nodule= large ie >0.5cm diameter
what type of skin lesions are macules and patches? how do they differ?
flat skin lesions
macules are small
patches are large
what type of skin lesions are pustules, vesicles and bullae? how do they differ?
raised
pustule= pus filled
vesicles= <0.5cm
bullae= >0.5 cm
what type of skin lesions are papules and nodules? how do they differ?
raised
papules are small
nodules are large
what is squamous cell carcinoma?
cancer of keratinocytes in the epidermis
what is the most common and second most common skin cancer?
most common= basal cell carcinoma
second most common= squamous cell carcinoma
what is the nature of invasion in squamous cell cacinoma?
local invasion into the dermis
can metastasise, common sights are lung, bone, brain and liver
what is basal cell carcinoma?
cancer of keratinocytes in the epidermis in the stratum basale
what are rf for squamous cell carcinoma?
UV light
fhx
lighter skin
actinic keratosis
what are rf for basal cell carcinoma?
UV light
fhx
lighter skin
what condition might increase risk of someone developing squamous cell carcinoma?
actinic keratosis
what is the nature of invasion in basal cell cacinoma?
slow growing local invasion into the dermis and doesnt metastasise
what does basal cell carcinoma look like?
nodule
pearly edges
central ulcer called a rodent ulcer
central fine telangiectasia
what is found at the center of a basal cell carcinoma nodule?
rodent ulcer
out of basal and squamous cell carcinoma which metastasises?
squamous cell
what are the types of basal cell carcinoma and how might they differ?
nodular= most common, pearly edges with rodent ulcer and central fine telangiectasia superficial= flat morpheic= yellow waxy plaque, scar like pigmented= dense and specks of colour
what acronym is used to remember how you describe a lesion and what does it stand for?
ABCDE: asymmetry border colour diameter evolution
what is the most deadly skin cancer?
malignant melanoma
what is malignant melanoma?
cancer of the melanocytes in the epidermis
what are rf for malignant melanoma?
UV light
fhx
lighter skin
what is the nature of invasion of malignant melanoma?
local invasion into the dermis
can metastasise, common sites include lung, bone, brain and liver
what does a malignant melanoma look like (go via ABDE)
Asymmetrical Border is irregular Colour is pigmented (dark) Diameter is over 6mm Evolution- might bleed, itch, crust over, ulcerate
how quick does referral need to be done for malignant melanoma v squamous v basal cell carcinoma?
malignant melanoma= urgent within 2 weeks
squamous= urgent within 2 weeks
basal= routine within 6 weeks
what ix are done for skin cancer? why are they done
bedside= dermatoscope bloods= ALP to check for bone mets, LFTs to check for liver mets imaging= CT/MRI/PET for staging biopsy= measure breslow thickness so see melanoma invasion extent, good for prognosis
what is breslow thickness?
it is a measure of melanoma invasion which can help judge prognosis and is done when a biopsy is taken
what is measured when a biopsy is taken is skin cancer and why?
breslow thickness
it shows the extent of melanoma invasion and can help judge prognosis
how is squamous cell carcinoma managed?
if in situ= cryotherapy
if invasive= surgical excision and radiotherapy
how is basal cell carcinoma managed?
non cosmetically challenging= surgical excision
cosmetically challenging= moh’s surgery
how is malignant melanoma managed?
early stage= surgical excision and lymph node biopsy
advanced but resectable= surgery and systemic therapy with nivolumab
advanced= systemic therapy (nivolumab) and treat mets
what systemic therapy is used in skin cancer for advanced malignant melanoma?
nivolumab
what type of skin condition is eczema?
inflammatory (NOT autoimmune)
what are rf of eczema?
pmhx/fhx of atopy eg food allergy, hay fever, asthma
filaggrin gene mutation
what does eczema look like?
distributed in flexures
dry, itchy, erythematous skin
lichenification if its chronic
what feature might you see in chronic eczema?
lichenification
where is eczema distributed?
in the flexures
describe atopic dermatitis. what skin condition does it fall under?
eczema
type I/IV hypersensitivity
IgE mediated
in the flexures
describe contact dermatitis. what skin condition does it fall under?
type IV hypersensitivity, delayed
often nickel/latex
two types are irritant and allergic