Mechanism of Learning/Memory Flashcards
these are good for study because we can select random mutations and study effects on behavior
drosophila
these are good to be used because they are similar anatomy to humans and are used to study explicit memory
mice
aplysia reflexive withdrawal of gill following stimulation of siphone
implicit memory
learning to ignore a repeated stimulus
habituation
repeated stimulation of siphon results in reduction of epsp in interneuron and motor neuron, and reduced withdrawal of the gills lasting minutes
short term habituation
continued stimulation of siphone results in habituation of gill reflex lasting weeks
long term habituation
decrease in the number of synaptic contacts between sensory and motor neurons requires blank
protein synthesis
decreasing the number of synaptic contacts is called blank and is in long term habituation
pruning,
repeated exposure to harmful stimulus causes heightened response/enhancement of reflex
sensitization
in sensitization, a blank neuron stimulated by a tail shock releases blank onto presynaptic terminal
facilitator, serotonin
serotonin causes an increase in blank which activates blank
cAMP, PKA
closing K channels too soon causes blank
prolonged depolarization
increase glutamate from sensory cell
heterosynaptic facilitation
learning to associate one type of stimulus with another
classical conditioning
converting short term memory to long term
consolidation
consolidation involves changes in gene expression and blank
protein synthesis
high cAMP leads to prolonged activation of blank which activates blank transciption facotr which codes for blank
PKA, CREB, gene expression
short term memory storage has a change in the amount of nt release from blank, alter blank influx, and change in opening/closing of blank
presynaptic cell, calcium, K+ channels
long term memory storage changes the number of blank which leads to gene expression and blank which takes a while to occur
synapses, protein synthesis
gene products generated during long term storage can only be used where
at that specific synapse