Ch 12 - NT Release Flashcards

0
Q

sodium influx and k efflux causes blank because when blocked, the cell can still be blank

A

no nt release, artificially depolarized

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1
Q

nt release is caused by blank of presynaptic cell

A

depolarization

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2
Q

elimination of blank from the extracellular solution blocks synaptic transmission

A

calcium

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3
Q

graded depolarization of the presynaptic cell cause graded blank currents

A

inward Calcium

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4
Q

synapse model that shows dependence of nt release in the auditory brainstem

A

calyx of held

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5
Q

delay between pre and post synaptic action potential

A

1-2 ms (synaptic delay)

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6
Q

calcium channels open up blank than na channels

A

slower

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7
Q

once calcium influx occurs, nt release occurs blank

A

rapidly

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8
Q

calcium sensor binds blank calcium ions to trigger release

A

5

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9
Q

nt are released in discrete amounts called blank

A

quanta (synaptic vesicle)

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10
Q

a blank potential creates a mini epsp

A

quantal

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11
Q

a release of neurotransmitter is always a blank of quanta

A

multiple

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12
Q

capacitance increases during blank of nt

A

exocytosis

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13
Q

capacitance decreases during blank of nt

A

endocytosis

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14
Q

two types of exocytosis

A

full, kiss and run

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15
Q

these regulate the reserve pool of vesicles tethered to actin

A

synapsisns

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16
Q

synapsisns are vesicular peripheral membrane blank

A

proteins

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17
Q

synapsisns release from vesicle during blank, which mobilizes vesicle to be transferred from reserve pool to docking at blank

A

Calcium influx, active zone

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18
Q

these proteins are for targeting of vesicles to active zone

A

rab proteins

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19
Q

rab proteins are also blank membrane proteins

A

vesicular peripheral

20
Q

blank is required for vesicles to fuse with membrane

A

energy

21
Q

two snare proteins

A

vesicular snare, target membrane snare

22
Q

vsnare proteins are on the blank

A

vesicle

23
Q

tsnare proteins are on the blank

A

cell membrane

24
Q

vsnare example

A

synaptobrevin

25
Q

tsnare examples

A

syntaxin, snap-25

26
Q

vsnare and tsnare bind with blank which bring the cell membrane vesicles together

A

each other

27
Q

vesicular bound protein that binds 5 calcium ions

A

synaptotagmin

28
Q

calcium binding triggers interaction of the blank domains with blank

A

C2, phospholipid membrane

29
Q

most prevalent protein in vesicle

A

vsnare

30
Q

pumps H+ ions into vesicle

A

v-atpase

31
Q

H+ gradient export serves as driving force to import neurotransmitter

A

H+/Nt Antiport

32
Q

like the rope that pinches the vesicle off the membrane during endocytosis

A

dynamin

33
Q

modulation of synaptic effictiveness

A

synaptic plasticity

34
Q

blank or blank modulations can result in plasticity

A

presynaptic, postsynaptic

35
Q

repetitive train of stimuli presented to presynaptic cell

A

tetanic stimulation

36
Q

increases epsp amplitude following tetanic stimulation of presynaptic cell

A

potentiation

37
Q

decreased epsp amplitude following prolonged periods of high frequency stimulation

A

depression

38
Q

during potentiation, blank exceeds blank capacity

A

calcium influx, buffering

39
Q

residual calcium enhances blank release during potentiation

A

synaptic vesicle

40
Q

tiniest form of individual neuron memory

A

synaptic plasticity

41
Q

during depression, synaptic vesicles become blank at active zone

A

depleted

42
Q

synapses that regulate calcium influx into presynaptic terminal

A

axo axonic

43
Q

another protein for docking/fusion but isnt a snare

A

munc18

44
Q

calcium sensor protein involved in vesicle release

A

synaptotagmin

45
Q

synaptic plasticity potentiation and depression are blank cell mechanisms

A

presynaptic

46
Q

presynaptic inhibition in axo axonic synapses blank calcium influx

A

reduces

47
Q

presynaptic facilitation in axo axonic synapses blank calcium influx

A

enhance