Mansonella

Question 1

Species

Answer 1

• Mansonella ozzardi

• Mansonella perstans

• Mansonella streptocerca

Question 2

Vectors

• M. ozzardi:

Answer 2

• Culicoides midge, Simulium blackfly

Question 3

Vector/s

M. perstans:
M. streptocerca:

Answer 3

• Culicoides midge

Question 4

Epidemiology

__________
• Endemic in West, East, and Central Africa
• Central and South America

_______
• Old World species: West and Central Africa

_______
• New World species: Central and South America, Caribbean Islands

Answer 4

Mansonella perstans

Mansonella streptocerca

Mansonella ozzardi

Question 5

Biology: Mansonella perstans

Microfilaria

Answer 5

• Unsheathed
• Nuclei extending to the tip of the tail

Question 6

Biology: Mansonella ozzardi

Microfilaria

Answer 6

• Unsheathed

• No nuclei at the tip of the tail

Question 7

Biology: Mansonella streptocerca

• Microfilaria

Answer 7

• Unsheathed
• Nuclei extend to the tip of the hooked tail

Question 8

Mansonella perstans

Adults in_____ cavity
or_____ cavity,

less frequently in____

Answer 8

peritoneal; pleural

pericardium

Question 9

Mansonella ozzardi

Adults in

Answer 9

subcutaneous tissues

Question 10

Mansonella streptocerca

Adults in____, less
than 1 mm From the skin

Answer 10

dermis

Question 11

Pathogenesis and Clinical Manifestations

• Generally____ presentation

• Many are asymptomatic especially those living in the____ regions

Answer 11

mild

endemic

Question 12

Pathogenesis and Clinical Manifestations

• Commonly asymptomatic

• If with symptoms, related to migrating adult worms

• Pericarditis, pleuritis
• Angioedema, pruritus, fever, headache, arthralgia, fatigue neuropsychiatric manifestations
• Calabar-like swelling, hydrocele
• Kampala or Ugandan Eye Worm

Answer 12

• Mansonella perstans

Question 13

• Kampala or Ugandan Eye Worm

Answer 13

• Mansonella perstans

Question 14

Pathogenesis and Clinical Manifestations

• Majority are asymptomatic

• If with symptoms

• Fever, pruritus, arthralgia, headache, rashes, lymphadenopathy, edema, pulmonary symptoms, eosinophilia
• Corneal lesions: keratitis

Answer 14

Mansonella ozzardi

Question 15

Corneal lesions:

Answer 15

keratitis

Question 16

Pathogenesis and Clinical Manifestations

• Most are asymptomatic

• If with symptoms

• Pruritus, dermatitis, hyperpigmented lesions on the torso, papular eruptions
• Eosinophilia
• No subcutaneous nodules

Answer 16

Mansonella streptocerca

Question 17

Diagnosis

• Diagnostic Stage

• Microfilaria in the blood stream

Answer 17

M. ozzardi, M. perstans

Question 18

Diagnosis

• Diagnostic Stage

Microfilaria in skin snips

Answer 18

• M. streptocerca

Question 19

Diagnosis

• Habitat of Adult Worm

• M. perstans:

Answer 19

• Peritoneal cavity, pleural cavity, pericardial cavity

Question 20

Diagnosis

• Habitat of Adult Worm

M. ozzardi

Answer 20

• Subcutaneous tissue

Question 21

Diagnosis

• Habitat of Adult Worm

M streptocerca

Answer 21

• Dermis less than 1mm from skin

Question 22

Diagnosis

• Molecular detection

Answer 22

• RT-PCR

• LAMP

Question 23

Diagnosis

Answer 23

Molecular detection
Serologic testing

Question 24

Treatment

Answer 24

• No optimal treatment
• Ivermectin
• Diethylcarbamazine plus mebendazole