Intro Prt 2 Flashcards
SPECIAL TYPES OF INFECTION
- Autoinfection
- Hyperinfection or Superinfection
Infected individual becomes his own direct source of infection
Autoinfection
Ex. Enterobiasis through hand-to-mouth transmission - In enterobiasis, infection may occur through hand-to-mouth transmission.
Infective eggs may end up in the hands by scratching the perianal areas where the gravid females lay their eggs.
Autoinfection
Infected individual is further infected with same species leading to massive infection
Hyperinfection or Superinfection
Ex. Capillaria philippinensis, Strongyloides stercoralis -
An alteration in the normal life cycle of Strongyloides results in a large increase in worm burden, which may lead to severe debilitation or even death due to an increase in the proportion of rhabditiform larvae that transform into filariform larvae while in the gut.
Hyperinfection or Superinfection
Female adult worms can be OVIPAROUS or LARVIPAROUS
Hyperinfection
Superinfection
There are no males in the parasitic portion of the life-cycle.
parasitic
(parthenogenetic)
_______adult female worm undergo_______meaning, the adult female worm produces embryonated eggs even in the absence of an adult male worm, even if thereis no fertilization.
Strongyloides stercoralis
parthenogenesis
The egg may hatch even inside the intestine liberating rhabdiliform larva that may also further develops to become filariform larva this filariform nerve penetrates the intestinal mucosa or perianal skin and migrate back to the small intestine to become an adult worm. This cycle repeats again and again and again resulting to________.
hyperinfection
AGENTS OF TRANSMISSION
Vehicle/ Fomites
Vector
AGENTS OF TRANSMISSION
•: non-living entity
•: living entity
Vehicle or Fomites
Vector
transports pathogens plus plays a role in the life cvcle of pathogen
Biological Vector
While carrying and transporting the organism develops further or even reproduces inside the vector
Biological Vector
(Malaria inside mosquito)
Biological vector
organism that only transports a pathogen
Mechanical Vector
(Flies, cockroaches that feed on fecal material with parasites)
Mechanical vector
MODES OF TRANSMISSION
PPACISB
Peroral
Percutaneous
Arthropod vector
Congenital transmission
Inhalation of Airborne eggs
Sexual intercourse
Blood-borne transmission
MODE OF TRANSMISSION
(Contaminated Food and Water): MC source; majority of cestodes, trematodes and intestinal protozoans like amoeba
Peroral
MODE OF TRANSMISSION
hookworm, strongyloides, schistosoma
Percutaneous (Skin Penetration)
MODE OF TRANSMISSION
: malaria, filaria, leishmania, trypanosoma
Arthropod Vector
MODE OF TRANSMISSION
toxoplasma (transplacental), ancylostoma and strongyloides (transmammary)
Congenital
Transmission
MODE OF TRANSMISSION
: enterobius
Inhalation of Airborne Eggs
MODE OF TRANSMISSION
: Trichomona vaginalis, giardia, entamoeba
Sexual Intercourse
MODES OF TRANSMISSION
: malaria
Blood-borne Transmission
DIRECT EFFECTS
MTEIN
Mechanical injury
Traumatic damage
Enzymatic interference
Invasion and destruction
Nutrient deprivation
May be inflicted by a parasite by means of pressure)as it grows larger
Mechanical Injury
Hydatid cyst causes blockage blood vessels producing infraction to different organs like liver, lungs, muscle, and other parts of the body
Mechanical Injury
Insect bite causes skin lesions or an ascaris lumbricoides heavy infection causing obstruction of the intestine wc needs surgical intervention
Traumatic Damage
E. histolytica trophozoites secrete______ proteases which digest cellular material in the colon and may consequently result to amoebic ulcer
Enzymatic Interference
cysteine
Invasion and Destruction
______invades RBC -› RBC rupture
__________to liver -› granuloma formation
_______destroying intestinal villi
Plasmodium
Schistosoma japonicum
Hookworms
• D. latum competes with host Vit B12 supply -> megaloblastic anemia
Nutrient Deprivation
INDIRECT EFFECTS
Excessive proliferation of certain tissues due to invasion by some parasites can also cause tissue damage in man
Tissue damage may be caused by immunological response of the host
MECHANISM OF IMMUNE EVASION
HAII
Host mimicry
Antigenic variat
Immune suppression
Intracellular sequestration
E. histolytica produces Suppressor factor that inhibits monocyte movement
Immune Suppression
Surface protein variation in T. brucei gambiense
Antigenic Variation
• E. granulosus carries blood group antigens
Host Mimicry
T. gondii multiplies inside macrophages
Intracellular Sequestration
EFFECTS OF HOST ON THE PARASITE
SDH
Sickle cell disease
Duffy blood group sytem
High protein diet
:
• protection against P. falcifarum malaria
Sickle cell disease
:
increases susceptibility to P. vivax malaria
Duffy blood group system
not suitable for intestinal protozoan development
High protein diet
- The stage in the life cycle at which the parasite is able to initiate an infection to its host.
INFECTIVE STAGE
- is the life cycle stage that (exits the definitive host found in specimen like feces, urine, or biopsy sample.
DIAGNOSTIC STAGE
Life cycle of Ascaris lumbricoides
Unfertilized egg & fertilized unembryonated egg, adult worms recovered in feces =
Embyronated egg =
diagnostic stage
infective stage
Between infection and evidence of
symptoms
Clinical Incubation Period/Incubation Period
infection and demonstration of
infection by laboratory means (there is laboratory testing invloved)
Biological Incubation Period/Pre-Patent Period
CLASSIFICATION OF PARASITES
Helminths
Protozoans
Arthropods
Helminths are
Multicellular
2 types of Helminths
Platyhelminths
Nemathelminths
Platyhelminths (Flatworms)
- Class: Trematoda (Flukes)
- Class: Cestoda (Tapeworms)
- Class:_____ (Flukes)
- Class:_____ (Tapeworms)
Trematoda
Cestoda
Nemathelminths
1. Class:______ (Roundworms)
Nematoda
Protozoans are
Unicellular
- Flat and Segmented
CESTODA
- Flat and Unsegmented
TREMATODA
4 main divisions of protozoas
SCAM
Sarcodina
Ciliophora
Apicomplexa
Mastigophora
- parasites that contain an apical structure that is used for burrowing a cell so that the parasite can get inside the cell
Apicomplexa
- uses flagellate as locomotory apparatus
Mastigophora
- uses pseudopods as locomotory apparatus just like an amoeba
Sarcodina
- uses ciliates for locomotion
Ciliophora
= the onlv medicallv
important parasite (that uses ciliates)
Balantidium coli