Liver and gluconeogenisis

Question 1

What can be used to synthesis glucose in conditions of carbohydrate deprivation

Answer 1

Lactate
glycerol
monosaccarides
glucogenic AA’s

Question 2

What converts glucose-6-phosphate to glucose in gluconeogenisis

Answer 2

Glucose-6-phosphatase

Question 3

What converts fructose-1,6-bisphosphate to fructose-6-phosphate

Answer 3

fructose-1,6-bisphosphatase

Question 4

How is pyruvate converted in phosphophenol pyruvate in gluconeogenisis

Answer 4

Pyruvate is converted to oxaloacetate by pyruvate carboxylase; and oxaloacetate is converted to phosphophenol pyruvate by PEP carboxylase

Question 5

What are the intermediates in gluconeogenisis?

Answer 5

Pyruvate
Oxaloacetate
Phosphophenol pyruvate
glycerate-2-phosphate
glycerate-3-phosphate
1,3-bisphosphoglycerate
dihydroxyacetate phosphate
glyceraldehyde-3-phosphate
fructose-1.6-bisphosphate
fructose-6-phosphate
glucose-6-phosphate
glucose

Question 6

What is the physiological circulating glc conc

Answer 6

3.9-6.7 mM

Question 7

What is the average fastic glc conc

Answer 7

4.4-5 mM

Question 8

What are the irreversible steps in glycolysis

Answer 8

Glucose -> glucose-6-phosphate via hexokinase

Fructose-6-phosphate -> glucose-1,6-bisphosphate
via phosphofructokinase

Phosphophenol pyruvate -> pyruvate