Aerobic respiration Flashcards
What is the order of the intermediated in the TCA cycle?
Citrate Isocitrate alpha-ketoglutarate succinylCoA succinate fumarate malate oxaloacetate - combines with acteylCoA to form citrate
What can citrate be used for in biosynthesis
Fatty acids, sterols
What can alpha-ketoglutarate be used for in biosynthesis
glutamine via transamination, which can then form other amino acids, purines
What can malate be used for in biosynthesis
can form pyruvate by action of malic enzyme
What can oxaloacetate be used for in biosynthesis
it can form phosphophenol pyruvate via PEP carboxylase
which can then go on to form glucose
aspartate via transamination which can then form other amino acids, pyrimidines
pyruvate can be converted into oxaloacetate via pyruvate carboxylase
What enzyme converts citrate to isocitrate?
Aconitase
What does aconitase do?
converts citrate to isocitrate in the TCA cycle, needs Fe
What enzyme converts isocitrate to alpha-ketoglutarate?
Isocitrate dehydrogenase
What does isocitrate dehydrogenase do?
Converts isocitrate to alpha-ketoglutarate producing a CO2 and 2H
What enzyme converts alpha-ketoglutarate to succinyl CoA?
Ketoglutarate dehydrogenase
What does ketoglutarate dehydrogenase do?
Converts alpha-ketoglutarate to succinyl CoA producing CO2 and 2H, adding CoASH
What enzyme converts succinyl CoA to succinate?
Succinate thiokinase
What does succinate thiokinase do?
Converts succinyl CoA to succinate releasing CoA and GTP
What converts succinate to fumarate
Succinate dehydrogenase
What does succinate dehydrogenase do?
Converts succinate to fumarate producing FADH2
What converts fumarate to malate
Fumarase
What does fumarase do?
Converts fumarate to malate
What converts malate into oxaloacetate
malate dehydrogenase
What does malate dehydrogenase do?
Converts malate to oxaloacetate
What converts oxaloacetate to citrate?
Citrate synthase
What does pyruvate carboxylase do?
Converts pyruvate to oxaloacetate
What does PEP carboxylase do?
converts oxaloacetate to phosphophenol pyruvate
What does malic enzyme do?
Converts malate to pyruvate
What effect does ADP have on isocitrate dehydrogenase?
It activates it
What effect does NADH have on isocitrate dehydrogenase?
It inhibits it
What effect does NADH have on ketoglutarate dehydrogenase?
It inhibits it
What effect does succinyl CoA have on ketoglutarate dehydrogenase?
It inhibits it
What effect does NADH have on citrate synthase?
It inhibits it
What effect does succinyl CoA have on citrate synthase?
It inhibits it
What metal is needed for aconitase
Fe
