Kidney function 1 Flashcards
What are the slit proteins
Nephrin and podocin
What type of cell is a podocyte
tubular epithelial
What are the types of nephron
Cortical = 85% Juxtamedullary = 15%
What type of cells make up the vase recta
peritubular capillaries
Describe renal handling of PAH (para-aminohippuric acid)
Some filtration, all excretion, no reabsorbed
How does filtration get affected by molecular charge
Anions are less able to cross, and cations are more freely filtered
Why is are acidic drugs not freely filtered
Albumin binds acidic drugs therefors protecting them from filtration
What is a normal GFR
125 mls/min
Typical urine output
1.5 L/day
What type of cells make up the proximal tubule
Single layer of coloumnar cells w/ microvilli on the apical membrane with lots of mitochondria
What are the three transporters that reabsorb glucose
GLUT transporters
Na+ dependent glucose transport
Na+-K+ ATPase
How are organic anions secreted in the PCT
OA- (organic anion) exchanged for dicarboxylate (DC-) via organic anion transporters OAT1, OAT3; DC pumped in for Na+ to keep conc grad.
DC- produced in metabolism; OA- pumped out via ATP dependent transporters
How are organic bases secreted in PCT
Cations enter via organic cation transporters (OCT2
Then exported to tubule lumen via multidrug and toxin extrusion proteins (MATE 1,k) in exchange for H+
What are the transporters involved in organic anion secretion
OAT1, OAT3
organic anion transporter
What are the transporters involved in organic cation sectreation
MATE1, MATE2-K
multidrug and toxin extrusion proteins
