Lecture 43

Question 1

There are two isoforms of COX (1 and 2.) COX 1 is ______ active, whereas COX 2 is ______ (usually by trauma or inflammatory response) and is present in immuno-competent cells.

Answer 1

COX 1 is CONSTITUTIVE, whereas COX 2 is INDUCIBLE and is present in immuno-competent cells.

Question 2

COX enzymes have 2 activities: _______ and ______ to form PGH2.

Answer 2

CYCLIZATION and PEROXIDATION

Question 3

____ is the protaglandin involved with development, regulation, and activity of many immune cells.

Answer 3

PGE2

Question 4

_____ had the opposite effect of Thromboxanes in areas where blood clots should not be forming.

Answer 4

PGI2

Question 5

Aspirin works by blocking both COX enzymes. The ____ group of Aspirin binds to ____ on the COX enzymes.

Answer 5

ACETYL group of aspirin bind SERINE on COX