Lecture 15

Question 1

How do you calculate genetic distance using recombination frequency?

Answer 1

genetic distance = # of recombinants/total offspring X 100

Question 2

What is positional cloning and why is it preferential to use it in humans over calculating recombination frequency as was done with flies?

Answer 2

Positional Cloning is a way to map and isolate disease genes using marker genes. It is preferential over recomb frequency calculations because it is hard to control human mating, humans produce a small number of offspring in each generation, and the time between generations is long.

Question 3

Becker’s Muscular Dystrophy shows a(n) X-linked ______ mode of inheritance.

Answer 3

Becker’s Muscular Dystrophy shows an X-LINKED RECESSIVE mode of inheritance

Question 4

Huntington’s disease, and Osteogenesis Imperfecta show a(n) ______ ______ mode of inheritance.

Answer 4

Huntington’s disease and Osteia Imperfecta show an AUTOSOMAL DOMINANT mode of inheritance.

Question 5

Cystic Fibrosis shows a(n) _____ _____ mode of inheritance.

Answer 5

Cystic Fibrosis shows an AUTOSOMAL RECESSIVE mode of inheritance.