Lecture 41

Question 1

Chylomicrons contain apo____ and are assembled in the _____.

Answer 1

They contain apoB48 and are assembled in the INTESTINES.

Question 2

Chylomicrons acquire ____ and ____ from HDL in the plasma.

Answer 2

Acquire apoC-II and apoE from HDL

Question 3

apo C-II binds to _____ lipase on the surface of non-hepatic tissues.

Answer 3

LIPOPROTEIN lipase

Question 4

Chylomicron remnants, depleted of FFA and Glycerol, return apo ____ to HDL.

Answer 4

They return apoC-II to HDL

Question 5

Chylomicron remnants with apo____ and apo____ bind apo____ receptors on hepatocytes, resulting in the uptake of Chylomicron remnants.

Answer 5

Remnants with apoE and apoB48 bind apoE receptors on hepatocytes, resulting in the uptake of the remnants.

Question 6

HDL and VLDL are both assembled in the ____, though HDL can be assembled in the intestine as well. VLDL contains apo____

Answer 6

LIVER. VLDL contains apoB100

Question 7

VLDL acquires ____ and ____ from HDL, but then returns both, at which point it becomes ____.

Answer 7

Acquires apoC-II and apoE from HDL, but then returns both, at which point it becomes LDL.

Question 8

Cholesterol Ester Transfer Protein (CEPT) deficient individuals have increased _____, putting them at lower risk for heart disease.

Answer 8

they have increased HDL

Question 9

Familial Hypercholesterolemia is autosomal _____, and arises from a defect (of which there are 4 classes) in the LDL receptor.

Answer 9

autosomal DOMINANT