Lecture 42 Flashcards
In adipocytes, Glycerol-3-P can be formed by reducing _____ using NADH, whereas in the liver it can be formed by direct phosphorylation of Glycerol via the enzyme ________.
In adipocytes, DHAP is reduced to for Glycerol-3-P, whereas in the liver it can be formed via the enzyme GLYCEROL KINASE
Phospholipase ____ acts on phosphatidylinositol to form arachidonic acid. It is inhibited by ______ (i.e. Cortisol.)
Phospholipase A2 acts on phosphatidylinositol to form arachidonic acid. It is inhibited by GLUCOCORTICOIDS.
Phospholipase ____ is found in the liver, and its action activates the PIP2 system
Phospholipase C is found in the liver
_____ serve as precursors to Sphingomyelin and Glycosphingolipids
CERAMIDES
_____ CoA is the precursor for Sphingolipids in general. Sphingosine is synthesized from _____CoA and the AA _____.
PALMITOYL CoA. Sphingosine is synthesiszed from PALMITOYL CoA and SERINE.
Tay Sachs disease results from a deficiency in the enzyme Beta-_________. It is characterized by accumulation of _______ and has symptoms such as cherry-red _____, muscular weakness, and blindness.
Deficiency in Beta-HEXOSAMINIDASE A. It is characterized by accumulation of GANGLIOSIDES and has symptoms such as cherry-red MACULA…
Gaucher disease results from a deficiency in Beta-______. It is characterized by accumulation of gluco_______ and has symptoms such as hepato_______ and osteoporosis of long bones.
Results from deficiency in Beta-GLUCOSIDASE. Accumulation of glucocerebrosides and has symptoms such as hepatoSPLENOMEGALY and osteoporosis of long bones.
Nieman-Pick disease results from a deficiency in _______. This results in accumulation of ______, leading to symptoms such as cherry-red _____, neurodegeneration, and hepato______.
Deficiency in SPHINGOMYELINASE resulting in accumulation of SPHINGOMYELIN, leading to symptoms such as cherry-red MACULA, neurodegeneration, and hepatoSPLENOMEGALY.
