Lecture 39

Question 1

Triacylglycerol Lipase is activated by ______ via PKA.

Answer 1

activated by PHOSPHORYLATION

Question 2

The _____ shuttle is the major way Long chain fatty acids are oxidized. This beta-oxidation occurs within the _____ of the cells.

Answer 2

CARNITINE shuttle. Beta-oxidation of long chain fatty acids occurs in the MITOCHONDRIAL MATRIX

Question 3

____ catalyzes the rate limiting step in fatty acid oxidation which binds Carnitine to fatty acyl CoA. It is inhibited by _____ CoA.

Answer 3

CPT1. It is inhibited by MALONYL CoA.

Question 4

CPT2 removes _____ from fatty acyl CoA once it passes the inner mitochondrial membrane.

Answer 4

Removes CARNITNE

Question 5

Oxidation of fatty acyl CoA in the mito produces 3 important products: _____ (used at complex II in ETC), _____ (used at complex I in ETC), and ______ (that enters into TCA.)

Answer 5

FADH2, NADH, and Acetyl CoA

Question 6

MCADD is an _____ recessive mutation in the enzyme involved in the first step of _____ chain fatty acid oxidation.

Answer 6

AUTOSOMAL recessive mutation in the enzyme involved in the first step of MEDIUM chain fatty acid oxidation.

Question 7

D-beta-hydroxybutarate can be converted back to acetoacetate to eventually reform 2 molecules of ______.

Answer 7

Eventually form 2 molecules of ACETYL CoA