Lecture 20

Question 1

In the Hardy-Weinberg equilibrium equation, which variable do affected males represent for X-linked recessive diseases?

Answer 1

q

Question 2

What is the disease incidence represented as in the HW equation for an autosomal dominant disease?

Answer 2

2pq because homozygous for the disease would likely die off, so heterozygotes would be the affected ones in a population. This should basically be equal to 2q, because the disease allele will be so heavily favored against in this situation that p will be basically = 1, so 2(1)(q) = 2q.

Question 3

____ ____ can cause changes in allele frequency in a small population by random chance.

Answer 3

Genetic Drift