Lecture 3 10/14/24 Flashcards
What are fungal nasal granulomas?
uncommon localized infection of the nasal mucosa resulting in granulomatous inflammation
What causes fungal nasal granuloma?
various mycotic and bacterial pathogens
What is the pathophysiology of fungal nasal granuloma?
-causative agent attracts macrophages to site
-macrophages induce tissue damage and granulomatous inflammation
-granuloma disrupts normal airflow
What are the clinical signs of fungal nasal granuloma?
-upper resp. noise/stertor
-dyspnea
-unilateral bloody or mucopurulent nasal discharge**
-disrupted nasal airflow**
How are fungal nasal granulomas diagnosed?
biopsy and culture/histopathology to identify hyphae/sporidium
What are the characteristics of sodium iodide treatment for fungal nasal granuloma?
-each treatment consists of one bottle of NaI going IV
-repeated every week until signs of iodism occur
-pretreat with dexamethasone for anaphylaxis
What are the signs of iodism?
-flaky skin
-ropey nasal discharge
-alopecia
How many NaI treatments does it typically take to develop iodism?
2 to 3 treatments
What is allergic rhinitis/enzootic nasal granuloma?
allergy against pollen or fungal spores
What causes acute allergic rhinitis?
mast cells and IgE mediate inflammation in a type 1 hypersensitivity
What causes enzootic nasal granuloma?
macrophage-mediated inflammation and repeated mast cell damage induces granulomas
What are the clinical signs of acute allergic rhinitis?
-sneezing
-nasal discharge
-pruritis
-dyspnea
-stertorous breathing
-inflamed mucosa
In addition to the allergic rhinitis signs, what other clinical sign is seen in enzootic nasal granuloma?
multiple focal granulomas or plaques throughout the nasal cavity
Which animals are most likely to get allergic rhinitis/enzootic nasal granuloma?
-channel island breeds
-younger animals
-animals in the summer/in warm and moist environments
How is allergic rhinitis/enzootic nasal granuloma diagnosed?
-visualization of nasal cavity
-intradermal skin testing/allergen ID; valuable animals only