Lecture 25 11/18/24 Flashcards
What is included in upper airway localization?
-nasal passages
-pharynx
-larynx
-trachea
-mainstem bronchi
Where does rhinitis localize to?
nasal passages
What is the diagnostic approach for nasal disease?
-exam and history
-clinicopathologic data
-radiology/CT scan
-scoping
-cytology/biopsy and culture
What are the potential causes of feline rhinitis?
-infectious
-immune mediated and/or inflammatory
-neoplastic
-dental/oral pathology
-foreign body
What are the infectious etiologies of feline rhinitis?
-feline rhinotracheitis virus/feline herpes
-feline calicivirus
-Chlamydia felis
-Mycoplasma spp.
-Bordetella spp.
-influenza virus
What are the characteristics of feline rhinotracheitis virus?
-unusual to have concurrent lower resp. problems
-generally more severe URT signs
-most cats exposed in their lifetime
-most infected cats develop latent infection in trigeminal ganglia
What are the characteristics of feline calicivirus?
-many strains with differing antigenicity and pathogenicity
-associated with oral ulcerations
-carrier state exists in absence of clinical signs
What are the characteristics of Mycoplasma felis?
-normal flora
-primary opportunistic pathogen
-typically only causes upper resp. tract disease
-culture and PCR often necessary for diagnosis
Which pathogens are common in coviral upper resp. infections in cats?
-FVR
-calicivirus
-FeLV
-FIV
Which bacteria is commonly found in feline upper resp. coinfections?
Chlamydia
What are the methods of transmission for feline upper resp. pathogens?
-direct
-indirect
-aerosol
Which factors impact the severity of URI clinical signs in cats?
-infecting dose and strain
-general health of cat
-pre-existing immunity
What are the clinical signs of an acute viral URI in cats?
-sneezing
-nasal discharge
-ocular signs
-pharyngitis/laryngitis
-drooling/gagging
-possible fever
How does FRV differ from feline calicivirus?
FRV:
-affinity for conjunctiva, upper airway epithelium, and cornea
-causes ocular problems
Calici:
-affinity for lung and oral mucosa
-causes pneumonia and oral ulcers
-less virulent
-may affect joint and cause limping
What are the characteristics of the course of infection for URI in cats?
-high morbidity for all etiologies
-higher mortality if cat is < 6 months old
-secondary bact. infections common
-disease course of 1-4 weeks depending on virus
What are the characteristics of virulent calicivirus?
-more common in adult, vaccinated cats
-can persist in environment for 28 days
-outbreaks appear self-limiting
-awareness and isolation required
-killed vaccine may help
What are the clinical signs of virulent calicivirus?
-fever
-URI
-oral ulcers
-nasal discharge
-ocular signs
-facial edema
-paw edema
-dermatitis on face, pinnae, and feet
What are the characteristics of chronic viral infections?
-predispose animal to opportunistic bacterial infections
-can damage epithelium and cause osteolysis of nasal turbinates without deformity of facial bones/soft palate
What are the characteristics of chronic FRV/herpes infection?
-almost all cats infected become chronic carriers
-periods of latency interspersed with episodes of infectious viral shedding
-shedding begins 1 week after stress and continues for another week
What are the characteristics of chronic calicivirus infection?
-continuous excretion from carrier cats
-may recover spontaneously
-most shed for 30 days prior to recovery
-carriers have individual amounts of virus shedding
What is the diagnostic approach for acute viral infection?
-history/PE
-conjunctival smears and IFA
-viral cultures
-viral PCR panels
What is the diagnostic approach for chronic viral infection?
-signs may persist due to mucosal damage and secondary bact. infection; may not find virus
-diagnosed through elimination
-history/clinical signs
-CT/rhinoscopy and biopsy
What are the treatment steps for acute viral URI?
-oral or nasogastric tube for nutritional support
-humidification of air
-possible decongestants
-fluids
-pain management
-ocular medication
-antibiotics for secondary bact. infections
How is pneumonia secondary to a URI treated?
-supplemental oxygen
-antibiotics
-nutritional support
-hospitalization
Which medications are used for treatment of ocular herpes?
-trifluoridine
-cidofovir
-antibiotics for secondary bact. infection
What is important about famciclovir?
can be used for severe, recurrent, or persistent disease; or if cat displays severe conjunctivitis, facial dermatitis, or keratitis