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Anatomy > Lecture 1 - Limb development > Flashcards

Lecture 1 - Limb development Flashcards

1
Q

What embryonic tissues give rise to the fore/hind limbs?

A

Ectoderm, dermatome, hypaxial portion of myotome, and somatic of lateral plate mesoderm

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2
Q

What gene is responsible for the timing of limb development?

A

Hox genes

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3
Q

What direction do things develop?

A

Proximal to distal

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4
Q

What gene is responsible for limb identity?

A

T-box

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5
Q

What are the three axes limbs develop in?

A

Proximodistal, dorsoventral, and crainocaudal

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6
Q

What proteins are active on the proximodistal axis?

A

Fgf 10, fgf 8m at AER

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7
Q

What is the AER?

A

Apical ectodermal ridge

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8
Q

What proteins are active on the crainocaudal axis?

A

Shh at ZPA

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9
Q

What is the ZPA?

A

Zone of polarizing activity

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10
Q

What protein/region is related to the dorsoventral axis?

A

Dorsal ectoderm/Wnt7a

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11
Q

What direction do the forelimbs rotate?

A

Dorsally

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12
Q

What direction do the hindlimbs rotate?

A

Venterally

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13
Q

What two specific things are the HOX genes responsible for?

A

Where the limb buds form and development at the specific location

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14
Q

What hox genes are responsible for different bones?

A

Hoxa and hoxd

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15
Q

How do Hox genes regulate bone growth in general?

A

overlap of expression

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16
Q

What are the two primary limb structures, in order?

A

Limb field - limb bud

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17
Q

What signal occurs during the induction of limb development?

A

Fgf8 induces fgf10

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18
Q

What is involved in the establishment of AER and ZPA centers?

A

Fgf10 induces Fgf8 (which induces Shh)

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19
Q

What are Fgf’s responsible for during AER and ZPA development?

A

Maintaining cell proliferation

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20
Q

What does Shh induce during outgrowth of the limb bud?

A

Fgf14

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21
Q

What are the main Fgf’s in early limb development?

A

Fgf8, 10, 14, and Shh

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22
Q

What are FGF10 and TBX5 responsible for together?

A

Induce epithelium to mesenchyme transition inducing the formation of the limb bud

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23
Q

What is the order of ridge development (fore vs hind)?

A

Forbud ridge appears 1-2 days before hindbud ridge

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24
Q

Where do limb buds originate from?

A

Ridges in ventrolateral body wall

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25
What are the two cell layers in the limb bud?
Mesenchyme core and ectoderm cover
26
What are the two parts of the mesenchyme core?
Lateral plate mesoderm and paraxial mesoderm
27
What does the ectoderm cover become?
Epidermis of skin, nails, and hands
28
What does the lateral plate mesoderm become?
Cartilage, bones, and general connective tissue
29
What does the paraxial mesoderm become?
Somites and skeletal muscle
30
What region expreses Fgf10 once limb bud has formed?
Lateral plate mesoderm
31
What does fgf10 initiate?
AER
32
How does Fgf10 initiate AER?
Wnt3a and beta-catenin
33
What does AER express?
Fgf8 and Fgf4, while maintaining Fgf10
34
What interaction is the limb bud dependent on?
Limb bud mesenchyme with AER
35
What does AER induce?
Proliferation of limb bud mesenchyme
36
Where is PZ?
Area of mesenchyme proximal to AER on caudal border
37
What is PZ?
Progress zone
38
Anatomically describe AER.
thickened, specialized epithelium at tip of the limb bud on dorsoventral border
39
What is affecting pattern formation in dorsal-vental axis?
non-AER ectoderm
40
Where does D/V signaling reside?
Dorsal ectoderm w/ Wnt7a morphogen
41
Where do precursor muscle cells, that migrate to limb bud, come from?
Ventrolateral myotome of somite
42
How is motor innervation formed in limb bud?
Ventral and dorsal branches of ventral rams follow growing muscle
43
What axis does AER direct pattern formation for?
PD
44
What happens at the terminal portion of each bud?
Becomes flattened = hands and footplates
45
What are the three limb segments?
Stylopod, Zeugopod, and Autopod
46
What does the stylopod become?
arm/thigh
47
What does the Zeugopod become?
forearm/leg
48
What does the Autopod become?
hand/feet
49
During PD axis development what occurs with the mesenchyme?
condenses into cartilage models
50
What are cartilage models?
templates for long bones
51
What is homology?
Shared ancestry between structure, gene, etc
52
What is the ZPA responsible for?
Pattern formation in Cr-Cd axis.
53
What does the ZPA express?
RA and Shh
54
What does the ZPA require for stimulation?
FGF8 and Wnt7
55
Where does FGF8 come from?
Apical ectodermal ridge
56
Where does Wnt7 come?
Dorsal ectoderm
57
What does the Shh gradient induce?
Nested (more or less) expression of mesenchymal Hox genes.
58
What happens when cells leave the ZPA?
stop expressing Shh
59
What do Shh decedents displace and where to?
non-ZPA cells cranially
60
What do Shh descendants give rise to?
Ulna, digits 4, 5, and contribute to 3
61
What do cells give rise to via long-range Shh signaling?
Digit 2 and parts of 3
62
What structures come from Shh independent cells?
Humerus, radius, and digit 1
63
What creates the pattern of development in the PD axis?
Gradient of RA and Fgf
64
What creates the pattern of development in Cr-Cd axis?
Graded Shh signaling
65
What is hairy2?
acts as clock that controls integrated development along all axes
66
How does the AER progress?
Will break up and only cover emerging digital ray
67
How do interdigital spaces form?
Apoptosis
68
What is a pentadactyl limb?
"ancestral" five digit condition, digit reduction occurred over evolution
69
What occurs in horses in regards to digit reduction?
post-patterning changes Digits 1 and 5 are eliminated Digits 2 and 4 fuse (via apoptosis)
70
What are artiodactyls?
Catttle and swine
71
What occurs in artiodactyls in regards to digit reduction?
patterning changes | Digit loss and central axis shift between digits 3 and 4
72
What is the order of digit loss?
I, V, II, and IV
73
What is isometry?
Proportional relationships are preserved as size changes
74
What is the solution to SA being small to amount of biologically active tissue?
Being overbuilt when small
75
What is the solution for something growing and muscles and bones being able to keep up with growth?
Allometry
76
What is allometry?
Proportional changes that deviate from isometry
77
What does the equation for allometry consider?
A trait of interest, body size, and relationship strength of the two
78
What is positive allometry?
Character increases faster than body size (b>1)
79
What is negative allometry?
Increases slower then size or decreases with size (0>b<1)
80
What happens if allometry is zero?
no relationship
81
What is an example of positive allometry?
Skeleton mass
82
What is an example of negative allometry?
heart rate and basal metabolic rate

Anatomy (44 decks)

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