L6: Anti-Infective Therapy Flashcards
____: drug used to treat any disease
____: substance that interferes with proliferation of microorganism
____: drug of natural origin (often dirt) that has anti-microbial properties
Chemotherapeutic
Antimicrobial
Antibiotic
True or False: Bacteriocidal antimicrobials inhibit growth while bacteriostatic kills
False
Bacteriocidal = kills
Bacteriostatic = inhibits growth
Which of the following antimicrobials would you give to an immune compromised patient or one with a lethal condition?
A. Bacteriostatic
B. Bacteriocidal
B. Bacteriocidal
True or False: A functioning immune system is required for use of bacteriocidal
False - required for bacteriostatic
What’s the difference between drug resistance and sensitivity?
Resistance: NOT inhibited by clinically achievable drug concentration
Sensitivity: Inhibited by clinically achievable drug concentration
True or False: Anti-microbials tests are all ex-vivo
False - all in vitro
Which tests are used to determine whether abx tx is effective at treating patient infection?
Antimicrobial sensitivity testing
What are the four antimicrobial sensitivity tests?
1) Kirby Bauer - QUALITATIVE
2) Minimum Inhibitory Concentration (MIC)
3) Minimum Bacteriocidal Concentrations (MBC)
4) Antimicrobial Serumcidal Concentrations
To read a Kirby-Bauer plate, measure the _____
zone of inhibition
What are the results of a Kirby-Bauer test?
1) Susceptible
2) Intermediate
3) Resistant
Which test is used to determine the LEAST amount of an antimicrobial agent required to inhibit growth (static or cidal)
Minimum Inhibitory Concentration.
Which test is used to determine the LEAST amount of an antimicrobial agent required to inhibit growth (static or cidal)
A. Kirby Bauer
B. Minimum Inhibitory Concentration (MIC)
C. Minimum Bacteriocidal Concentrations (MBC)
D. Antimicrobial Serumcidal Concentrations
B. Minimum Inhibitory Concentration (MIC)
True or False: Treatment should not exceed the MIC at site of infection
False - treatment SHOULD exceed the MIC at site of infection
How is the growth assesed in the MIC?
A. Plating cell suspensions
B. Turbidity
C. Size
B. Turbidity
In which of the following tests is an antibiotic diluted in broth containing the pt’s isolated in standard amounts and incubated?
A. Kirby Bauer
B. MIC
C. MBC
B. MIC
True or False: MBC test can be adapted to E test or microwell plate
False - MIC can
Which of the following tests is used to identify the MINIMUM amount of an antimicrobial agent required to KILL (bacteriocidal)?
A. Kirby Bauer
B. MIC
C. MBC
C. MBC
True or False: Both Kirby Bauer and MIC can inhibit growth that is either static or cidal
True
True or False: The MIC is always greater than or equal to the MBC. In some cases, levels that are less than or equal to the MBC are needed for efficacy
False
- MIC is always < or equal to MBC
- In some cases, levels greater than or equal to MBC are needed for efficacy
In the case where infection is inaccessible to immune system, the amount of anti-micobial at the site should ____ MBC
exceed