L30 - Gram+ Bacteria III Flashcards
1
Q
Clostridia
microbiology
A
- Gram+
- bacillus (racquet-shaped)
- obligate anaerobes
- capable of forming spores
2
Q
Clostridia tetani
pathogenesis
A
- Spores introduced from soil through a wound
- Bacteria grow and lyse in injured, anoxic wounds, and they release toxins
- Toxins transported intra-axonally to spinal neurons
3
Q
Clostridia tetani
toxins
A
- tetanospasmin
- Heavy chain - binds irreversibly to eukaryotic cells
- Light chain - blocks inhibitory receptors of muscle contraction
- tetanolysin
4
Q
Clostridia tetani
clinical manifestations
A
- Lock jaw
- Muscle spasming
5
Q
- Gram+
- bacillus (racquet-shaped)
- obligate anaerobes
- capable of forming spores
A
Clostridia
microbiology
6
Q
- Spores introduced from soil through a wound
- Bacteria grow and lyse in injured, anoxic wounds, and they release toxins
- Toxins transported intra-axonally to spinal neurons
A
Clostridia tetani
pathogenesis
7
Q
- tetanospasmin
- Heavy chain - binds irreversibly to eukaryotic cells
- Light chain - blocks inhibitory receptors of muscle contraction
- tetanolysin
A
Clostridia tetani
toxins
8
Q
- Lock jaw
- Muscle spasming
A
Clostridia tetani
clinical manifestations
9
Q
Clostridum botulinum
pathogenesis
A
- Heat resistant
- Boiling actually helps by creating an anaerobic environment
- Destroy toxin through pressure cooker
- Ingestion through food
- Release of neurotoxin in bloodstream
10
Q
Clostridia botulinum
toxicity
A
- Spores are only toxic in babies, adults are only prone to the toxin itself
- Honey should be avoided
- Neurotoxin prevents release of Ach
- Light chain prevents release of Ach
- Heavy chain binds the receptor
- Muscles are unable to contract
11
Q
Clostridia botulinum
clinical manifestations
A
- Cranial nerve impairment
- Paralysis
12
Q
- Heat resistant
- Boiling actually helps by creating an anaerobic environment
- Destroy toxin through pressure cooker
- Ingestion through food
- Release of neurotoxin in bloodstream
A
Clostridum botulinum
pathogenesis
13
Q
- Spores are only toxic in babies, adults are only prone to the toxin itself
- Honey should be avoided
- Neurotoxin prevents release of Ach
- Light chain prevents release of Ach
- Heavy chain binds the receptor
- Muscles are unable to contract
A
Clostridia botulinum
toxicity
14
Q
- Cranial nerve impairment
- Paralysis
A
Clostridia botulinum
clinical manifestations
15
Q
Clostridia perfringens
A
cause of gas gangrene
