L24 - Rheumatic Disease II Flashcards
1
Q
fybromyalgia
A
- syndrome (not a disease!) characterized by widespread body pain
- lack of inflammation means that it is futile to treat with anti-inflammatory agents
- does not exclude other diseases
2
Q
non-inflammatory arthritis characteristics
A
- Pain: worse in PM
- Stiffness: not frequent
- Redness: absent
- Swelling: yes-bony
3
Q
inflammatory arthritis characteristics
A
- Pain: worse in AM
- Stiffness: AM
- Redness: present
- Swelling: yes-soft
4
Q
treatments for osteoarthritis
A
- exercise and weight loss
- acetaminophen and NSAIDs
- synvisc (hylan A and B polymers)
- joint replacement
- No evidence supporting biological therapy
5
Q
measures to track response to lupus therapy
A
anti-DNA antibodies and complement levels (ANA levels are NOT useful)
6
Q
drugs for RA
A
Anti-Inflammatory Drugs
- aspirin
- NSAIDs
- steroids (prednisone)
Disease-modifying Anti-Rheumatic Drugs (DMARDs)
- methotrexate
- hydroxychloroquine
- azathioprine
- TNF antagonists
- IL-6R antagonists
- IL-1R antagonists
- anti-B-cell antibodies
- blockade of B7/CD28 signaling
7
Q
drugs for SLE
A
- sunscreen
- NSAIDs
- glucocorticoids
- antimalarials (hydroxychloroquine)
- immunosuppressives (methotrexate, azathioprine)
- antibodies targeting B-cells
8
Q
- syndrome (not a disease!) characterized by widespread body pain
- lack of inflammation means that it is futile to treat with anti-inflammatory agents
- does not exclude other diseases
A
fybromyalgia
9
Q
- Pain: worse in PM
- Stiffness: not frequent
- Redness: absent
- Swelling: yes-bony
A
non-inflammatory arthritis characteristics
10
Q
- Pain: worse in AM
- Stiffness: AM
- Redness: present
- Swelling: yes-soft
A
inflammatory arthritis characteristics
11
Q
“-cept”
A
drug that fuses to the FcR of IgG1
12
Q
“-mab”
A
drug that serves as a monoclonal antibody
13
Q
“-ximab”
A
drug that serves as a chimeric antibody
14
Q
“-zumab”
A
drug that serves as a humanized antibody
15
Q
drug that fuses to the FcR of IgG1
A
“-cept”
