L17 - Integration of Innate and Adaptive

Question 1

phases of T-cell activation

Answer 1

1. recognition phase
2. activation phase
3. effector phase
4. decline
5. memory

Question 2

how T-cells enter lymphoid organs

Answer 2

• rolling motion due to interaction between L-selecting (T-cell) and CD34 or GlyCAM (HEV)
• halting due to interaction between LFA-1 (T-cell) and ICAM-1 (HEV)

Question 3

how T-cells interact with APCs

Answer 3

• T-cell and APC
• CD2 and LFA-3
• LFA-1 and ICAM-1
• LFA-1 and ICAM-2
• ICAM-3 and DC-SIGN

Question 4

“first” signal for T-cell activation

Answer 4

interaction between MHC and TCR

Question 5

“second” T-cell activating signal

Answer 5

B7 (APC) with CD28 (T-cell)

Question 6

B7

Answer 6

ligand that binds to CD28 on T-cells and serves as an activating signal

Question 7

CD28

Answer 7

binds to B7 on APCs

Question 8

activation phase (T-cells)

Answer 8

1. IL-2 and IL-2R production
2. change in surface molecules
   
   • VLA-4 (binds to VCAM)
   • CD40L
3. differentiation into effector T-cells

Question 9

cytokines that promote T_H1 differentiation

Answer 9

IL-12

Question 10

cytokines that promote T_H2 differentiation

Answer 10

IL-4

Question 11

cytokines produced by T_H1 cells

Answer 11

IL-2, IFN-y, TNF

Question 12

cytokines produced by T_H2 cells

Answer 12

IL-4, IL-5, IL-10, IL-13

Question 13

CTLA-4

Answer 13

receptor that recognizes B7 to prevent further activation

Question 14

hyper immunoglobulin M (HIM) syndrome

Answer 14

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

Question 15

ligand that binds to CD28 on T-cells and serves as an activating signal

Answer 15

B7

Question 16

binds to B7 on APCs

Answer 16

CD28

Question 17

receptor that recognizes B7 to prevent further activation

Answer 17

CTLA-4

Question 18

genetic disorder marked by a lack of CD40L, resulting in no T-cell dependent antibody responses

Answer 18

hyper immunoglobulin M (HIM) syndrome