L26 - Transfusion and Transplant Immunology Flashcards
1
Q
hyperacute rejection
A
- minutes to hours
- preformed antibodies against AB or HLA antigens
- intravascular coagulation
2
Q
acute rejection
A
- days to years
- mostly T-cell mediated
- direct tissue destruction by T-cells
3
Q
chronic rejection
A
- months to years
- cellular and humoral
- leads to fibrosis and chronic inflammation
4
Q
strategies to prevent graft rejection
A
- match tissues
- immunosuppression with drugs
- immunosuppression with antibodies
5
Q
tissue matching strategy
A
- match ABO blood group
- match HLA
A, B, and DR most important
DP and DQ also sometimes used
