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M&I > L11 - Eicosanoids > Flashcards

L11 - Eicosanoids Flashcards

1
Q

cyclooxygenase

A

enzyme responsible for producing PGH2 from arachidonic acid

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1
Q

5-lipoxygenase (5-LO)

A

enzyme responsible for producing LTA4 from arachidonic acid

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1
Q
  • fever
  • GI smooth muscle constriction
  • GI cytoprotection
  • softens cervix
  • uterine contraction
  • relaxes smooth muscle in blood vessels
  • increases renal filtration
  • inhibits 5-LO
A

PGE2

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2
Q

intermediate PG produced by COX enzymes; it gives rise to other PGs

A

PGH2

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3
Q

PGD2

A
  • contracts bronchial airways
  • reduces body temperature during sleep
  • partially responsible for male baldness
  • major PG produced by mast cells
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4
Q

LTB4

A

neutrophil chemotaxis

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4
Q

LTA4

A

intermediate LT produced by 5-LO that gives rise to other LTs

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6
Q

PGH2

A

intermediate PG produced by COX enzymes; it gives rise to other PGs

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7
Q

can be measured in urine as a marker of LT production

A

LTE4

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8
Q

arachidonic acid

A

type of eicosanoid that is a precursor to prostaglandins and leukotrienes

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9
Q

enzyme responsible for producing LTA4 from arachidonic acid

A

5-lipoxygenase (5-LO)

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10
Q
  • contracts bronchial airways
  • reduces body temperature during sleep
  • partially responsible for male baldness
  • major PG produced by mast cells
A

PGD2

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11
Q

PGI2

A
  • vasodilator
  • increases renal filtration
  • inhibits platelet aggregation
  • relaxes smooth muscle in arteries and uterus
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12
Q

TXA2

A
  • constricts smooth muscle in blood vessels
  • bronchoconstrictor
  • enhances platelet aggregation
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14
Q

LTD4

A
  • bronchoconstriction
  • mucus production
  • eosinophil chemotaxis
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15
Q
  • vasodilator
  • increases renal filtration
  • inhibits platelet aggregation
  • relaxes smooth muscle in arteries and uterus
16
Q
  • constricts smooth muscle in blood vessels
  • bronchoconstrictor
  • enhances platelet aggregation
17
Q

LTE4

A

can be measured in urine as a marker of LT production

18
Q

neutrophil chemotaxis

19
Q

enzyme responsible for producing PGH2 from arachidonic acid

A

cyclooxygenase

20
Q

PGE2

A
  • fever
  • GI smooth muscle constriction
  • GI cytoprotection
  • softens cervix
  • uterine contraction
  • relaxes smooth muscle in blood vessels
  • increases renal filtration
  • inhibits 5-LO
21
Q
  • constricts smooth muscle except arterial vessels
  • bronchoconstrictor
  • uterine contractions
22
Q

intermediate LT produced by 5-LO that gives rise to other LTs

24
Q
  • bronchoconstriction
  • mucus production
  • eosinophil chemotaxis
25
Q

eicosanoid

A
  • 20-carbon chain fatty acid
  • derived from omega-3 and omega-6 fatty acids
  • generated by PLA2
26
Q

PGF2a

A
  • constricts smooth muscle except arterial vessels
  • bronchoconstrictor
  • uterine contractions

M&I (32 decks)

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