L11 - Eicosanoids Flashcards
1
Q
cyclooxygenase
A
enzyme responsible for producing PGH2 from arachidonic acid
1
Q
5-lipoxygenase (5-LO)
A
enzyme responsible for producing LTA4 from arachidonic acid
1
Q
- fever
- GI smooth muscle constriction
- GI cytoprotection
- softens cervix
- uterine contraction
- relaxes smooth muscle in blood vessels
- increases renal filtration
- inhibits 5-LO
A
PGE2
2
Q
intermediate PG produced by COX enzymes; it gives rise to other PGs
A
PGH2
3
Q
PGD2
A
- contracts bronchial airways
- reduces body temperature during sleep
- partially responsible for male baldness
- major PG produced by mast cells
4
Q
LTB4
A
neutrophil chemotaxis
4
Q
LTA4
A
intermediate LT produced by 5-LO that gives rise to other LTs
6
Q
PGH2
A
intermediate PG produced by COX enzymes; it gives rise to other PGs
7
Q
can be measured in urine as a marker of LT production
A
LTE4
8
Q
arachidonic acid
A
type of eicosanoid that is a precursor to prostaglandins and leukotrienes
9
Q
enzyme responsible for producing LTA4 from arachidonic acid
A
5-lipoxygenase (5-LO)
10
Q
- contracts bronchial airways
- reduces body temperature during sleep
- partially responsible for male baldness
- major PG produced by mast cells
A
PGD2
11
Q
PGI2
A
- vasodilator
- increases renal filtration
- inhibits platelet aggregation
- relaxes smooth muscle in arteries and uterus
12
Q
TXA2
A
- constricts smooth muscle in blood vessels
- bronchoconstrictor
- enhances platelet aggregation
14
Q
LTD4
A
- bronchoconstriction
- mucus production
- eosinophil chemotaxis
