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M&I > L28 - Gram+ Bacteria I > Flashcards

L28 - Gram+ Bacteria I Flashcards

1
Q

Staphylococcus aureus

microbiology

A
  • Gram+
  • pyogenic
  • coagulase+
  • aerobic and facultatively anaerobic
  • non-spore forming
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2
Q

Staphylococcus aureus

pathogenesis

A
  1. Transmission: direct contact with humans or inanimate objects
  2. Colonization: MSCRAMMs and immune invasion
  3. Damage
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3
Q

Staphylococcus aureus

MSCRAMMs

A

Fnbp (fibronectin binding protein) - binds to fibronectin in wounds

CNA (collagen N-terminal adhesin) - binds to collagen

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4
Q

Staphylococcus aureus

immune evasion

A
  • coagulase - converts fibrinogen to fibrin, allowing bacteria to hide in clots from neutrophils
  • catalase - neutralizes H2O2 in neutrophils
  • Protein A - binds Fc portion of antibodies
  • leukocidin - forms pores in leukocytes
  • biofilm
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5
Q

Staphylococcus aureus

clinical presentation

A
  • pimples, boils
  • localized inflammation
  • accumulation of pus
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6
Q
  1. Transmission: direct contact with humans or inanimate objects
  2. Colonization: MSCRAMMs and immune invasion
  3. Damage
A

Staphylococcus aureus

pathogenesis

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7
Q

Fnbp (fibronectin binding protein) - binds to fibronectin in wounds

CNA (collagen N-terminal adhesin) - binds to collagen

A

Staphylococcus aureus

MSCRAMMs

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8
Q
  • coagulase - converts fibrinogen to fibrin, allowing bacteria to hide in clots from neutrophils
  • catalase - neutralizes H2O2 in neutrophils
  • Protein A - binds Fc portion of antibodies
  • leukocidin - forms pores in leukocytes
  • biofilm
A

Staphylococcus aureus

immune evasion

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9
Q
  • pimples, boils
  • localized inflammation
  • accumulation of pus
A

Staphylococcus aureus

clinical presentation

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10
Q

Staphylococcus aureus

damage

A
  • peptidoglycan - reacts with TLR2
  • teichoic acid - adherence to mucosal cells
  • hemolysins - lyse RBCs
  • PVL - pore-forming toxin that targets neutrophils
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11
Q

Streptococcus

microbiology

A
  • Gram+
  • catalase-
  • facultative anaerobe
  • requires enriched medium containing blood
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12
Q

Streptococcus

clinical presentation

A

petachiae on the soft pallet

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13
Q

Streptococcus

transmission

A
  • direct contact with nasopharyngeal secretions or infected lesions
  • does NOT transmit from inanimate objects
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14
Q

petachiae on the soft pallet

A

Streptococcus

clinical presentation

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15
Q
  • direct contact with nasopharyngeal secretions or infected lesions
  • does NOT transmit from inanimate objects
A

Streptococcus

transmission

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16
Q

Streptococcus

pathogenesis

A
  • colonization with fimbriae
  • pyrogenic exotoxin
17
Q

Streptococcus

fimbriae

A
  • hair-like projection
  • inhibits phagocytosis
  • composed of lipotechoic acid and M proteins
18
Q

Streptococcus

treatment

A

penicillin

clindamycin

19
Q
  • colonization with fimbriae
  • pyrogenic exotoxin
A

Streptococcus

pathogenesis

20
Q
  • hair-like projection
  • inhibits phagocytosis
  • composed of lipotechoic acid and M proteins
A

Streptococcus

fimbriae

M&I (32 decks)

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