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M&I > L23 - Rheumatic Disease > Flashcards

L23 - Rheumatic Disease Flashcards

1
Q

rheumatoid factors

A

IgG and IgM antibodies produced in the synovium against the Fc portion of IgG

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2
Q

pannus

A

hyperplastic, villus-like projection of synovial tissue

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3
Q

ankylosis

A

fusion of a joint

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4
Q

pathogenesis of rheumatoid arthritis

A
  1. rheumatoid factors create immune complexes
  2. inflammation due to cytokines and complement
  3. pannus formation
  4. obstruction of fluid (containing nutrients) to cartilage
  5. delivery of degradative enzymes from pannus to cartilage
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5
Q

specific test for RA

A

cyclic citrullinated peptide (CCP) antibody test

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6
Q

types of antinuclear antibodies

A
  • antibodies to DNA
  • antibodies to histones
  • antibodies to non-histone protein bound to RNA
  • antibodies to nucleolar antigens
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7
Q

antiphospholipid antibodies in lupus

A
  • lupus anticoagulant
  • anticardiolipin antibodies
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8
Q

Smith antigen

A

nuclear antigen against which patients with lupus may produce antibodies; only present in 30% of SLE cases, but a highly specific indicator of the disease

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9
Q

primary vasculitis

A

vasculitis with unknown cause

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10
Q

secondary vasculitis

A

vasculitis that can be attributed to disease

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11
Q

anti-neutrophilic cytoplasmic antibody (ANCA)

A

antibody that forms against antigens in cytoplasm of nucleus; allows for a positive feedback loop in which neutrophils are activated by FcRs and recruit more neutrophils, which release more ANCA antigens

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12
Q

erythrocyte sedimentation rate (ESR)

A

measure of the length of fall of a column of RBCs over a given period of time; increased acute phase response results in lowered negative charge between RBCs, causing increased length of fall

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13
Q

vasculitis

A

inflammation that causes structural damage to a vessel wall

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14
Q

giant cell (temporal) arteritis

A

large vessel vaculitis

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15
Q

polyarteritis nodosa

A
  • vasculitis of medium vessels
  • presents with bowel pain, bleeding, muscle pain or weakness
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16
Q

granulamatosis with polyangitis (Wegener’s)

A
  • vasculitis of small and medium vessels
  • c-ANCA observed in 95% of cases
  • presents with hemoptysis, hematuria, palpable purpura
  • treat with cytoxan
17
Q

immune-mediated mechanisms of vasculitis

A
  1. immune complex mediated
  2. direct antibody attack
  3. ANCA
  4. T-cell mediated
18
Q

IgG and IgM antibodies produced in the synovium against the Fc portion of IgG

A

rheumatoid factors

19
Q

hyperplastic, villus-like projection of synovial tissue

A

pannus

20
Q

fusion of a joint

A

ankylosis

21
Q

cyclic citrullinated peptide (CCP) antibody test

A

specific test for RA

22
Q

nuclear antigen against which patients with lupus may produce antibodies; only present in 30% of SLE cases, but a highly specific indicator of the disease

A

Smith antigen

23
Q

vasculitis with unknown cause

A

primary vasculitis

24
Q

vasculitis that can be attributed to disease

A

secondary vasculitis

25
Q

antibody that forms against antigens in cytoplasm of nucleus; allows for a positive feedback loop in which neutrophils are activated by FcRs and recruit more neutrophils, which release more ANCA antigens

A

anti-neutrophilic cytoplasmic antibody (ANCA)

26
Q

measure of the length of fall of a column of RBCs over a given period of time; increased acute phase response results in lowered negative charge between RBCs, causing increased length of fall

A

erythrocyte sedimentation rate (ESR)

27
Q

inflammation that causes structural damage to a vessel wall

A

vasculitis

28
Q

large vessel vaculitis

A

giant cell (temporal) arteritis

29
Q
  • vasculitis of medium vessels
  • presents with bowel pain, bleeding, muscle pain or weakness
A

polyarteritis nodosa

30
Q
  • vasculitis of small and medium vessels
  • c-ANCA observed in 95% of cases
  • presents with hemoptysis, hematuria, palpable purpura
  • treat with cytoxan
A

granulamatosis with polyangitis (Wegener’s)

M&I (32 decks)

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