L21 - Anti-Inflammatory and Immunosuppressive Agents Flashcards
1
Q
azathioprine
A
pro-drug of 6MP; myelosuppressive via purine synthesis inhibition (de novo and salvage); must reduce dose if giving allopurinol
2
Q
mycophenolate mofetil
A
- inhibits de novo purine synthesis, resulting in preferential inhibition of lymphocytes
- rapid acting
- can cause GI upset
2
Q
- glucocorticosteroid
- anti-inflammatory potency of 5
- equivalent dose of 4mg
A
6a-methylprednisone
3
Q
- glucocorticosteroid
- anti-inflammatory potency of 25
- equivalent dose of 0.75mg
A
dexamethosome
3
Q
drug that inhibits mTOR
A
sirolimus
4
Q
mechanisms of glucocorticosteroids
A
- interfere with AP-1 binding; less cytokines
- decrease COX-2 mRNA stability
- decrease expression of adhesion molecules
- inhibit degranulation of granulocytes
5
Q
sirolimus
A
drug that inhibits mTOR; can inhibit wound healing
5
Q
- most basic glucocorticosteroid
- anti-inflammatory potency of 1
- equivalent dose of 20mg
A
cortisol
6
Q
cyclosporine/tacrolimus
A
drugs that decreases calcineurin
8
Q
prednisone
A
- glucocorticosteroid
- anti-inflammatory potency of 4
- equivalent dose of 5mg
9
Q
pro-drug of 6MP; myelosuppressive via purine synthesis inhibition
A
azathioprine
9
Q
- inhibits de novo purine synthesis, resulting in preferential inhibition of lymphocytes
- rapid acting
- can cause GI upset
A
mycophenolate mofetil
10
Q
refers to inhibition of bone marrow division
A
myelosuppression
12
Q
methotrexate
A
- DHFR inhibitor (de novo purine synthesis)
- can be nephrotoxic
- dosed once a week
13
Q
drug that decreases calcineurin
A
cyclosporine/tacrolimus
