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M&I > L21 - Anti-Inflammatory and Immunosuppressive Agents > Flashcards

L21 - Anti-Inflammatory and Immunosuppressive Agents Flashcards

1
Q

azathioprine

A

pro-drug of 6MP; myelosuppressive via purine synthesis inhibition (de novo and salvage); must reduce dose if giving allopurinol

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2
Q

mycophenolate mofetil

A
  • inhibits de novo purine synthesis, resulting in preferential inhibition of lymphocytes
  • rapid acting
  • can cause GI upset
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2
Q
  • glucocorticosteroid
  • anti-inflammatory potency of 5
  • equivalent dose of 4mg
A

6a-methylprednisone

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3
Q
  • glucocorticosteroid
  • anti-inflammatory potency of 25
  • equivalent dose of 0.75mg
A

dexamethosome

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3
Q

drug that inhibits mTOR

A

sirolimus

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4
Q

mechanisms of glucocorticosteroids

A
  • interfere with AP-1 binding; less cytokines
  • decrease COX-2 mRNA stability
  • decrease expression of adhesion molecules
  • inhibit degranulation of granulocytes
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5
Q

sirolimus

A

drug that inhibits mTOR; can inhibit wound healing

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5
Q
  • most basic glucocorticosteroid
  • anti-inflammatory potency of 1
  • equivalent dose of 20mg
A

cortisol

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6
Q

cyclosporine/tacrolimus

A

drugs that decreases calcineurin

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8
Q

prednisone

A
  • glucocorticosteroid
  • anti-inflammatory potency of 4
  • equivalent dose of 5mg
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9
Q

pro-drug of 6MP; myelosuppressive via purine synthesis inhibition

A

azathioprine

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9
Q
  • inhibits de novo purine synthesis, resulting in preferential inhibition of lymphocytes
  • rapid acting
  • can cause GI upset
A

mycophenolate mofetil

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10
Q

refers to inhibition of bone marrow division

A

myelosuppression

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12
Q

methotrexate

A
  • DHFR inhibitor (de novo purine synthesis)
  • can be nephrotoxic
  • dosed once a week
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13
Q

drug that decreases calcineurin

A

cyclosporine/tacrolimus

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15
Q

cortisol

A
  • most basic glucocorticosteroid
  • anti-inflammatory potency of 1
  • equivalent dose of 20mg
16
Q

6-mercaptopurine (6MP)

A

myelosuppressive drug that inhibits purine synthesis (de novo and salvage); must reduce dose if giving allopurinol

17
Q
  • DHFR inhibitor
  • can be nephrotoxic
  • dosed once a week
A

methotrexate

19
Q
  • glucocorticosteroid
  • anti-inflammatory potency of 4
  • equivalent dose of 5mg
A

prednisone

20
Q

myelosuppression

A

refers to inhibition of bone marrow division

21
Q

myelosuppressive drug that inhibits purine synthesis

A

6-mercaptopurine (6MP)

22
Q

6a-methylprednisone

A
  • glucocorticosteroid
  • anti-inflammatory potency of 5
  • equivalent dose of 4mg
23
Q

adrenocorticosteroids

A

steroids produced by the adrenal cortex; metabolic and anti-inflammatory side effects have not currently been separated

24
Q

dexamethosome

A
  • glucocorticosteroid
  • anti-inflammatory potency of 25
  • equivalent dose of 0.75mg

M&I (32 decks)

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