L12 - Sepsis Flashcards
1
Q
systemic inflammatory response syndrome (SIRS)
A
Two or more of the following:
- fever
- elevated or low WBC
- tachycardia
- tachypnea
2
Q
sepsis
A
SIRS plus infection
3
Q
severe sepsis
A
sepsis that is accompanied by low blood pressure treatable with fluids
4
Q
septic shock
A
sepsis with hypotension that does not resolve with fluids
5
Q
initiators of sepsis
A
PAMPs, superantigens, DAMPs
6
Q
LPS in sepsis
A
binds with CD14 via TLR4; results in TNFa, IL-1, and IL-6
7
Q
IL-10
A
anti-inflammatory cytokine
8
Q
treatment of sepsis
A
- stabilize
- clear microorganisms
- remove focus of infection
9
Q
Two or more of the following:
- fever
- elevated or low WBC
- tachycardia
- tachypnea
A
systemic inflammatory response syndrome (SIRS)
10
Q
SIRS plus infection
A
sepsis
11
Q
sepsis that is accompanied by low blood pressure treatable with fluids
A
severe sepsis
12
Q
sepsis with hypotension that does not resolve with fluids
A
septic shock
13
Q
anti-inflammatory cytokine
A
IL-10
14
Q
epidemiology of sepsis
A
- age: young or old
- underlying disease: neutropenia, chronic conditions, AIDS
- surgery or instrumentation
- prior drug therapy
- other: childbirth, trauma, ulceration
15
Q
sepsis cascades
A
- complement
- kinin-kallikrein
- coagulation
- fibrinolysis
